ArrayExpress Uploader0mouse8386arrayexpress_sid8The cytokine IL-10 deactivates macrophages and has been shown to impair resistance to mycobacterial infection. We have infected...E-GEOD-14316/profile/8773/arrayexpressuploader014cytokinegenomemacrophagemycobacterial infectiontuberculosisDec.12, 2014Falsetranscription-profiling-of-mouse-lung-from-a-straiE-GEOD-14316_A-AFFY-36Transcription profiling of mouse lung from a strain overexpressing IL-10 under control of the macrophage-specific CD68 promoter (macIL-10tg mice) after Mycobacterium tuberculosis infectionNov.24, 2014The cytokine IL-10 deactivates macrophages and has been shown to impair resistance to mycobacterial infection. We have infected transgenic mice overexpressing IL-10 under control of the macrophage-specific CD68 promoter (macIL-10tg mice) with Mycobacterium tuberculosis by aerosol and found increased bacterial loads in the lungs of macIL-10tg mice. To identify programs of genes regulated by IL-10 and associated with increased mycobacterial replication, genome-wide expression analysis was performed. Experiment Overall Design: Impact of IL-10 pulmonary gene expression in mouse M. tuberculosis infectionhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-14316http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-14316/samples/