{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSE14316GSM357934": {}}, {"GSE14316GSM357935": {}}, {"GSE14316GSM357936": {}}, {"GSE14316GSM357937": {}}, {"GSE14316GSM357938": {}}, {"GSE14316GSM357939": {}}, {"GSE14316GSM357940": {}}, {"GSE14316GSM357941": {}}, {"GSE14316GSM357942": {}}, {"GSE14316GSM357943": {}}, {"GSE14316GSM357944": {}}, {"GSE14316GSM357945": {}}, {"GSE14316GSM357946": {}}, {"GSE14316GSM357947": {}}], "id": 8386, "ownerprofile_id": "arrayexpress_sid", "platform": 8, "summary_wrapped": "The cytokine IL-10 deactivates macrophages and has been shown to impair resistance to mycobacterial infection. We have infected...", "geo_gse_id": "E-GEOD-14316", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 14, "tags": ["cytokine", "genome", "macrophage", "mycobacterial infection", "tuberculosis"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-of-mouse-lung-from-a-strai", "geo_id_plat": "E-GEOD-14316_A-AFFY-36", "name": "Transcription profiling of mouse lung from a strain overexpressing IL-10 under control of the macrophage-specific CD68 promoter (macIL-10tg mice) after Mycobacterium tuberculosis infection", "created": "Nov.24, 2014", "summary": "The cytokine IL-10 deactivates macrophages and has been shown to impair resistance to mycobacterial infection. We have infected transgenic mice overexpressing IL-10 under control of the macrophage-specific CD68 promoter (macIL-10tg mice) with Mycobacterium tuberculosis by aerosol and found increased bacterial loads in the lungs of macIL-10tg mice. To identify programs of genes regulated by IL-10 and associated with increased mycobacterial replication, genome-wide expression analysis was performed. Experiment Overall Design: Impact of IL-10 pulmonary gene expression in mouse M. tuberculosis infection", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-14316", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-14316/samples/"}