Dataset: Transcription profiling of human hepatocytes treated with 25-hydroxycholesterol and the antiviral state it conveys against the HCV

Hepatitis C virus (HCV) infection is a global health problem. A number of studies have implicated a direct role of cellular lipid metabolism in the HCV life cycle and inhibitors of the mevalonate pathway have been demonstrated to result in an antiviral state within the host cell. Transcriptome profiling was also conducted on Huh-7 human hepatoma cells bearing subgenomic HCV replicons with and without treatment with 25-hydroxycholesterol (25-HC), an inhibitor of the mevalonate pathway that alters lipid metabolism, to assess metabolic determinants of pro- and antiviral states within the host cell. Experiment Overall Design: compound treatment and time course

Species:

human

Samples:

10

Source:

E-GEOD-14204

Updated:

Dec.12, 2014

Registered:

Jun.19, 2014