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Home › Dataset Library › Transcription profiling by array of human familial hypercholesterolemia to identify atherosclerotic markers in human blood

Dataset: Transcription profiling by array of human familial hypercholesterolemia to identify atherosclerotic markers in human blood

Atherosclerosis is characterized by thickening of the arterial wall and is the primary cause of the coronary artery disease and...

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Atherosclerosis is characterized by thickening of the arterial wall and is the primary cause of the coronary artery disease and cerebrovascular disease, two of the most common causes of illness and death worldwide. One of the leading risk factors for development of atherosclerosis is familial hypercholesterolemia. Familial hypercholesterolemia is an autosomal dominant disorder, which is caused by mutations mainly located in the low-density lipoprotein receptor (LDLR) gene. It is characterized by elevated levels of low-density lipoprotein cholesterol, the presence of tendon xanthomas, and premature cardiovascular disease. Aim of this study was to find atherosclerotic markers in white blood cells of patients compared to healthy controls. None of these patients exhibited symptoms of atherosclerosis by standard diagnostic methods; however, transcriptome analysis of blood RNA indicated changes in ubiquitin proteolysis and cell adhesion system as expected in initiation steps of atherosclerosis. Experiment Overall Design: Five patients diagnosed with Familial hypercholesterolemia and five age, sex, BMI and smoking status matched controls contributed blood from which total RNA from white blood cells was isolated. RNA samples were analyzed using Affymetrix microarrays and two groups were compared for differentially expressed genes.

Species:
human

Samples:
10

Source:
E-GEOD-13985

Updated:
Dec.12, 2014

Registered:
Sep.11, 2014


Factors: (via ArrayExpress)
Sample disease clinical treatment
GSE13985GSM351336 familial hypercholesterolemia Altrain (lovastatin)
GSE13985GSM351337 familial hypercholesterolemia none
GSE13985GSM351338 familial hypercholesterolemia Silvacor (simvastatin)
GSE13985GSM351339 familial hypercholesterolemia Sortis (atorvastatin)
GSE13985GSM351337 familial hypercholesterolemia none
GSE13985GSM351341 none none
GSE13985GSM351341 none none
GSE13985GSM351341 none none
GSE13985GSM351341 none none
GSE13985GSM351341 none none

Tags

  • artery
  • artery disease
  • atherosclerosis
  • cell
  • cerebrovascular disease
  • coronary artery
  • coronary artery disease
  • disease
  • familial hypercholesterolemia
  • hypercholesterolemia
  • lipoprotein
  • tendon

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