{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 3114, "factors": [{"GSE13906GSM349848": {"disease state": "normal", "cell type": "gamma delta T cell"}}, {"GSE13906GSM349848": {"disease state": "normal", "cell type": "gamma delta T cell"}}, {"GSE13906GSM349850": {"disease state": "nasal T cell lymphoma", "cell type": "gamma delta T cell"}}, {"GSE13906GSM349850": {"disease state": "nasal T cell lymphoma", "cell type": "gamma delta T cell"}}, {"GSE13906GSM349852": {"disease state": "chronic active Epstein-Barr virus infection", "cell type": "gamma delta T cell"}}, {"GSE13906GSM349852": {"disease state": "chronic active Epstein-Barr virus infection", "cell type": "gamma delta T cell"}}, {"GSE13906GSM349852": {"disease state": "chronic active Epstein-Barr virus infection", "cell type": "gamma delta T cell"}}, {"GSE13906GSM349852": {"disease state": "chronic active Epstein-Barr virus infection", "cell type": "gamma delta T cell"}}, {"GSE13906GSM349856": {"disease state": "normal", "cell type": "lymphocyte"}}, {"GSE13906GSM349856": {"disease state": "normal", "cell type": "lymphocyte"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "The contribution of chronic antigen stimulation to the occurrence of lymphoproliferative disorder (LPD) with the gamma-delta T-cell...", "pubmed_id": 20132662, "geo_gse_id": "E-GEOD-13906", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 10, "tags": ["cancer", "cell", "ebv infection", "genome", "lymphoma"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-of-human-nk-cell-associate", "geo_id_plat": "E-GEOD-13906_A-AFFY-44", "name": "Transcription profiling of human NK-cell associated receptors expression in EBV-positive gamma-delta T cell lines.", "created": "Sep.11, 2014", "summary": "The contribution of chronic antigen stimulation to the occurrence of lymphoproliferative disorder (LPD) with the gamma-delta T-cell lineage is unclear, despite the fact that Epstein-Barr virus (EBV) positive T-cell LPD is derived from antigen-stimulated cytotoxic T-cells. Given the possible association of antigen stimulation with the development of cytotoxic T-cell LPD, we compared gene expression patterns in Epstein-Barr virus (EBV)-positive gamma-delta T-cell lines derived from patients with nasal T-cell lymphoma and chronic active EBV infection and those in gamma-delta T-cells from healthy volunteers. Three EBV-positive gamma-delta T-cells lines, SNT cells (SNT-8, SNT-13 and SNT-15), were used in this study. SNT-8 was established from patients with nasal T-cell lymphoma and SNT-13, -15 were established from patients with chronic active EBV infection (Zhang Y, et al., Br J Cancer 94:599-608, 2006). All the SNT cells exhibits common rearrangement of Vgamma9-JgammaP and Jdelta3 genes. The gamma-delta T-cells obtained from healthy volunteers were expanded ex vivo by 1 microM of zoledronate (ZOL) plus IL-2 for 14 days incubation. Experiment Overall Design: We compared gene expression profiling in 3 EBV-positive positive gamma-delta T-cells lines with those in gamma-delta T cells obtaied from a healthy volunteer.  Global gene expression was analyzed using the Affymetrix Human Genome U133 2.0 Plus GeneChip Set. Analysis of variance (ANOVA) was done using GeneSifter\u00ae (VizXLabs). Values of P<0.05 were considered to be a statistically significant difference.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-13906", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-13906/samples/"}