ArrayExpress Uploader0mouse5562arrayexpress_sid6Leukemia cells from mice with MLL-AF10 AML were fractionated into separate sub-populations on the basis of c-kit expression, which...E-GEOD-13692/profile/8773/arrayexpressuploader08cellleukemiaDec.12, 2014Falsetranscription-profiling-of-human-mll-af10-myeloidE-GEOD-13692_A-AFFY-45Transcription profiling of human MLL-AF10 myeloid leukemia cellular subsetsNov.10, 2014Leukemia cells from mice with MLL-AF10 AML were fractionated into separate sub-populations on the basis of c-kit expression, which correlates with MLL LSC frequency (Somervaille and Cleary, 2006). The sorted AML sub-populations exhibited substantial differences in their frequencies of AML CFCs/LSCs (mean 14-fold) and morphologic features, consistent with a leukemia cell hierarchy with maturation through to terminally differentiated neutrophils. Experiment Overall Design: Leukemic splenocytes from four mice with MLL-AF10 AML were sub-fractionated in to c-kit high and c-kit negative sub-populations by FACS.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-13692http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-13692/samples/