{"platform": 6, "owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSE13690GSM344110": {}}, {"GSE13690GSM344116": {}}, {"GSE13690GSM344124": {}}, {"GSE13690GSM344125": {}}, {"GSE13690GSM344126": {}}, {"GSE13690GSM344127": {}}, {"GSE13690GSM344128": {}}, {"GSE13690GSM344183": {}}, {"GSE13690GSM344185": {}}, {"GSE13690GSM344227": {}}, {"GSE13690GSM344229": {}}, {"GSE13690GSM344231": {}}, {"GSE13690GSM344236": {}}, {"GSE13690GSM344237": {}}, {"GSE13690GSM344239": {}}, {"GSE13690GSM344240": {}}, {"GSE13690GSM344241": {}}, {"GSE13690GSM344242": {}}, {"GSE13690GSM344243": {}}, {"GSE13690GSM344246": {}}, {"GSE13690GSM344247": {}}, {"GSE13690GSM344249": {}}, {"GSE13690GSM344250": {}}, {"GSE13690GSM344254": {}}, {"GSE13690GSM344255": {}}, {"GSE13690GSM344259": {}}, {"GSE13690GSM344260": {}}, {"GSE13690GSM344262": {}}, {"GSE13690GSM344265": {}}, {"GSE13690GSM344267": {}}, {"GSE13690GSM344268": {}}, {"GSE13690GSM344270": {}}, {"GSE13690GSM344271": {}}, {"GSE13690GSM344273": {}}, {"GSE13690GSM344275": {}}, {"GSE13690GSM344277": {}}, {"GSE13690GSM344284": {}}, {"GSE13690GSM344285": {}}], "id": 5561, "ownerprofile_id": "arrayexpress_sid", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-13690", "summary_wrapped": "The genetic programs that promote retention of self-renewing leukemia stem cells (LSCs) at the apex of cellular hierarchies in acute...", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 38, "tags": ["acute myeloid leukemia", "cancer", "chromatin", "leukemia", "myeloid leukemia"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-13690_A-AFFY-45", "slug": "transcription-profiling-of-mouse-mll-leukemias-who", "geo_gds_id": "", "name": "Transcription profiling of mouse MLL leukemias (whole BM)", "created": "Nov.10, 2014", "summary": "The genetic programs that promote retention of self-renewing leukemia stem cells (LSCs) at the apex of cellular hierarchies in acute myeloid leukemia (AML) are not known.  In a mouse model of human AML, LSCs exhibit variable frequencies that correlate with the initiating MLL oncogene and are maintained in a self-renewing state by a transcriptional sub-program more akin to that of embryonic stem cells (ESCs) than adult stem cells.  The transcription/chromatin regulatory factors Myb, Hmgb3 and Cbx5 are critical components of the program and suffice for Hoxa/Meis-independent immortalization of myeloid progenitors when co-expressed, establishing the cooperative and essential role of an ESC-like LSC maintenance program ancillary to the leukemia initiating MLL/Hox/Meis program.  Enriched expression of LSC maintenance and ESC-like program genes in normal myeloid progenitors and poor prognosis human malignancies links the frequency of aberrantly self-renewing progenitor-like cancer stem cells to prognosis in human cancer.  Experiment Overall Design: Samples are from five separate cohorts of mice where leukemia was initiated using distinct MLL fusion oncogenes: MLL-AF1p (n=9), MLL-AF10 (n=8), MLL-GAS7 (n=5), MLL-AF9 (n=5) and MLL-ENL (n=7). Four normal BM samples were also used as controls.", "geo_gse_id": "E-GEOD-13690", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-13690/samples/"}