{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 3079, "factors": [{"GSE13487GSM339960": {"genotype": "wild type", "compound": "RAF inhibitor #1"}}, {"GSE13487GSM339960": {"genotype": "wild type", "compound": "RAF inhibitor #1"}}, {"GSE13487GSM339962": {"genotype": "sh2B-raf (doxycycline inducible)", "compound": "RAF inhibitor #1"}}, {"GSE13487GSM339962": {"genotype": "sh2B-raf (doxycycline inducible)", "compound": "RAF inhibitor #1"}}, {"GSE13487GSM339964": {"genotype": "shGFP", "compound": "RAF inhibitor #2"}}, {"GSE13487GSM339965": {"genotype": "shB-Raf (doxycycline inducible)", "compound": "RAF inhibitor #1"}}, {"GSE13487GSM339966": {"genotype": "wild type", "compound": "BAY-43-9006"}}, {"GSE13487GSM339966": {"genotype": "wild type", "compound": "BAY-43-9006"}}, {"GSE13487GSM339968": {"genotype": "sh2B-raf (doxycycline inducible)", "compound": "BAY-43-9006"}}, {"GSE13487GSM339968": {"genotype": "sh2B-raf (doxycycline inducible)", "compound": "BAY-43-9006"}}, {"GSE13487GSM339970": {"genotype": "shGFP", "compound": "none"}}, {"GSE13487GSM339971": {"genotype": "shB-Raf (doxycycline inducible)", "compound": "none"}}, {"GSE13487GSM339972": {"genotype": "sh2B-raf (doxycycline inducible)", "compound": "none"}}, {"GSE13487GSM339970": {"genotype": "shGFP", "compound": "none"}}, {"GSE13487GSM339971": {"genotype": "shB-Raf (doxycycline inducible)", "compound": "none"}}, {"GSE13487GSM339972": {"genotype": "sh2B-raf (doxycycline inducible)", "compound": "none"}}, {"GSE13487GSM339970": {"genotype": "shGFP", "compound": "none"}}, {"GSE13487GSM339971": {"genotype": "shB-Raf (doxycycline inducible)", "compound": "none"}}, {"GSE13487GSM339978": {"genotype": "wild type", "compound": "DMSO"}}, {"GSE13487GSM339979": {"genotype": "sh2B-raf (doxycycline inducible)", "compound": "DMSO"}}, {"GSE13487GSM339978": {"genotype": "wild type", "compound": "DMSO"}}, {"GSE13487GSM339979": {"genotype": "sh2B-raf (doxycycline inducible)", "compound": "DMSO"}}, {"GSE13487GSM339982": {"genotype": "shGFP", "compound": "doxycycline"}}, {"GSE13487GSM339983": {"genotype": "shB-Raf (doxycycline inducible)", "compound": "doxycycline"}}, {"GSE13487GSM339984": {"genotype": "sh2B-raf (doxycycline inducible)", "compound": "doxycycline"}}, {"GSE13487GSM339982": {"genotype": "shGFP", "compound": "doxycycline"}}, {"GSE13487GSM339983": {"genotype": "shB-Raf (doxycycline inducible)", "compound": "doxycycline"}}, {"GSE13487GSM339984": {"genotype": "sh2B-raf (doxycycline inducible)", "compound": "doxycycline"}}, {"GSE13487GSM339982": {"genotype": "shGFP", "compound": "doxycycline"}}, {"GSE13487GSM339983": {"genotype": "shB-Raf (doxycycline inducible)", "compound": "doxycycline"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Unsupervised hierarchical clustering revealed a strong similarity in gene modulation resulting from either compound treatment or BRAF...", "pubmed_id": 19276360, "geo_gse_id": "E-GEOD-13487", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 30, "tags": ["melanoma"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-by-array-of-human-melano-3", "geo_id_plat": "E-GEOD-13487_A-AFFY-44", "name": "Transcription profiling by array of human melanoma cells with doxycycline-inducible RNAi-mediated knockdown of B-Raf", "created": "Sep.11, 2014", "summary": "Unsupervised hierarchical clustering revealed a strong similarity in gene modulation resulting from either compound treatment or BRAF ablation mediated by RNA interference relative to DMSO-treated control samples . Experiment Overall Design: We have generated melanoma A375 cells stably expressing a shRNA construct for doxycycline-inducible knockdown of B-Raf (2 mg/ml Dox, 48h). Small molecule treatment was at 1000nM R341787, 24h.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-13487", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-13487/samples/"}