{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "human", "factors": [{"GSE13280GSM335273": {}}, {"GSE13280GSM335243": {}}, {"GSE13280GSM335272": {}}, {"GSE13280GSM335266": {}}, {"GSE13280GSM335253": {}}, {"GSE13280GSM335271": {}}, {"GSE13280GSM335264": {}}, {"GSE13280GSM335267": {}}, {"GSE13280GSM335269": {}}, {"GSE13280GSM335238": {}}, {"GSE13280GSM335239": {}}, {"GSE13280GSM335265": {}}, {"GSE13280GSM335270": {}}, {"GSE13280GSM335252": {}}, {"GSE13280GSM335234": {}}, {"GSE13280GSM335275": {}}, {"GSE13280GSM335237": {}}, {"GSE13280GSM335257": {}}, {"GSE13280GSM335268": {}}, {"GSE13280GSM335250": {}}, {"GSE13280GSM335251": {}}, {"GSE13280GSM335242": {}}, {"GSE13280GSM335256": {}}, {"GSE13280GSM335246": {}}, {"GSE13280GSM335241": {}}, {"GSE13280GSM335274": {}}, {"GSE13280GSM335258": {}}, {"GSE13280GSM335240": {}}, {"GSE13280GSM335244": {}}, {"GSE13280GSM335233": {}}, {"GSE13280GSM335261": {}}, {"GSE13280GSM335254": {}}, {"GSE13280GSM335263": {}}, {"GSE13280GSM335260": {}}, {"GSE13280GSM335259": {}}, {"GSE13280GSM335236": {}}, {"GSE13280GSM335249": {}}, {"GSE13280GSM335235": {}}, {"GSE13280GSM335276": {}}, {"GSE13280GSM335247": {}}, {"GSE13280GSM335255": {}}, {"GSE13280GSM335245": {}}, {"GSE13280GSM335248": {}}, {"GSE13280GSM335262": {}}], "id": 1483, "pop_total": 0, "platform": 3, "summary_wrapped": "We addressed the clinical significance and mechanisms behind in vitro cellular responses to ionising radiation (IR)-induced DNA double...", "pubmed_id": 18941120, "geo_gse_id": "E-GEOD-13280", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 44, "tags": [], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-of-human-paediatric-acute", "geo_id_plat": "E-GEOD-13280_A-AFFY-33", "name": "Transcription profiling of human paediatric acute lymphoblastic leukaemia", "created": "Jun.19, 2014", "summary": "We addressed the clinical significance and mechanisms behind in vitro cellular responses to ionising radiation (IR)-induced DNA double strand breaks in 74 paediatric ALL patients. We found an apoptosis-resistant response in 36% of patients and an apoptosis-sensitive response in the remaining 64% of leukaemias. Global gene expression profiling of 11 apoptosis-resistant and 11 apoptosis-sensitive ALLs revealed abnormal up-regulation of multiple pro-survival pathways in response to IR in apoptosis-resistant leukaemias and differential post-transcriptional activation of the PI3-Akt pathway was observed in representative resistant cases. It is possible that abnormal pro-survival responses to DNA damage provide one of the mechanisms of primary resistance in ALL . Experiment Overall Design: Twenty two B-precursor ALL tumours (11 responsive to IR-induced DNA damage and 11 resistant) were analysed before and 8 hours after exposure to 5 Gy IR, using the Affymetrix HG_U133A (GPL96) platform.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-13280", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-13280/samples/"}