ArrayExpress Uploader0mouse5511arrayexpress_sid6DAP12 is a transmembrane protein, expressed as a disulfide-bonded homodimer and bears an immunoreceptor tyrosine-based activation motif...E-GEOD-13140/profile/8773/arrayexpressuploader04basalcellmacrophageproteinsurfacetyrosineDec.12, 2014Falsernai-profiling-of-mouse-macrophage-response-to-dapE-GEOD-13140_A-AFFY-45RNAi profiling of mouse macrophage response to DAP12 knockdown in basal conditions and in the response to IL-4 Basal and IL-4 response in DAP12 (TYROBP) KO miceNov.10, 2014DAP12 is a transmembrane protein, expressed as a disulfide-bonded homodimer and bears an immunoreceptor tyrosine-based activation motif (ITAM). DAP12 is broadly expressed in hematopoietic cells and associates with a variety of cell surface receptors in lymphoid and myeloid cells. Macrophages express several DAP12-associated receptors including triggering receptors expressed by myeloid cells (TREM)-1,2 and 3, myeloid DAP12-associating lectin (MDL)-1, CD200R like proteins CD200R3/R4 and CD300C/D/E . Experiment Overall Design: The current experiment was designed to evaluate the effect of DAP12 knockdown on macrophage gene expression, both in basal conditions and in the response to IL-4.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-13140http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-13140/samples/