{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSE13140GSM329112": {}}, {"GSE13140GSM329111": {}}, {"GSE13140GSM329110": {}}, {"GSE13140GSM329109": {}}], "id": 5511, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "DAP12 is a transmembrane protein, expressed as a disulfide-bonded homodimer and bears an immunoreceptor tyrosine-based activation motif...", "geo_gse_id": "E-GEOD-13140", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 4, "tags": ["basal", "cell", "macrophage", "protein", "surface", "tyrosine"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "rnai-profiling-of-mouse-macrophage-response-to-dap", "geo_id_plat": "E-GEOD-13140_A-AFFY-45", "name": "RNAi profiling of mouse macrophage response to DAP12 knockdown in basal conditions and in the response to IL-4 Basal and IL-4 response in DAP12 (TYROBP) KO mice", "created": "Nov.10, 2014", "summary": "DAP12 is a transmembrane protein, expressed as a disulfide-bonded homodimer and bears an immunoreceptor tyrosine-based activation motif (ITAM). DAP12 is broadly expressed in hematopoietic cells and associates with a variety of cell surface receptors in lymphoid and myeloid cells. Macrophages express several DAP12-associated receptors including triggering receptors expressed by myeloid cells (TREM)-1,2 and 3, myeloid DAP12-associating lectin (MDL)-1, CD200R like proteins CD200R3/R4 and CD300C/D/E . Experiment Overall Design: The current experiment was designed to evaluate the effect of DAP12 knockdown on macrophage gene expression, both in basal conditions and in the response to IL-4.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-13140", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-13140/samples/"}