{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "human", "factors": [{"GSE12854GSM322537": {"genotype": "PKA RI-alpha over expression"}}, {"GSE12854GSM322537": {"genotype": "PKA RI-alpha over expression"}}, {"GSE12854GSM322537": {"genotype": "PKA RI-alpha over expression"}}, {"GSE12854GSM322540": {"genotype": "PKA RII-beta over expression"}}, {"GSE12854GSM322540": {"genotype": "PKA RII-beta over expression"}}, {"GSE12854GSM322540": {"genotype": "PKA RII-beta over expression"}}, {"GSE12854GSM322534": {"genotype": "wild type"}}, {"GSE12854GSM322534": {"genotype": "wild type"}}, {"GSE12854GSM322534": {"genotype": "wild type"}}], "id": 3024, "pop_total": 0, "platform": 4, "summary_wrapped": "The regulatory subunit of cAMP-dependent protein kinase (PKA) exists in two isoforms, RI and RII, which distinguish the PKA isozymes,...", "geo_gse_id": "E-GEOD-12854", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 9, "tags": ["cell", "protein"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-12854_A-AFFY-44", "slug": "transcription-profiling-by-array-of-human-ovarian", "geo_gds_id": "", "name": "Transcription profiling by array of human ovarian cancer cells over-expressing PKA regulatory subunits", "created": "Sep.10, 2014", "summary": "The regulatory subunit of cAMP-dependent protein kinase (PKA) exists in two isoforms, RI and RII, which distinguish the PKA isozymes, type I (PKA-I) and type II (PKA-II). Evidence obtained from a variety of different experimental approaches has shown that the relative levels of type I and type II PKA in cells can play a major role in determining the balance between cell growth and differentiation. RI? transfected cells exhibit hyper-proliferative growth and RII? transfected cells revert to a relatively quiescent state. Profiling by microarray revealed equally profound changes in gene expression between RI?, RII?, and parental OVCAR cells.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12854", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12854/samples/"}