ArrayExpress Uploaderarrayexpress_sidhumanPKA RI-alpha over expressionPKA RI-alpha over expressionPKA RI-alpha over expressionPKA RII-beta over expressionPKA RII-beta over expressionPKA RII-beta over expressionwild typewild typewild type302404The regulatory subunit of cAMP-dependent protein kinase (PKA) exists in two isoforms, RI and RII, which distinguish the PKA isozymes,...E-GEOD-12854/profile/8773/arrayexpressuploader19cellproteinDec.12, 2014FalseE-GEOD-12854_A-AFFY-44transcription-profiling-by-array-of-human-ovarianTranscription profiling by array of human ovarian cancer cells over-expressing PKA regulatory subunitsSep.10, 2014The regulatory subunit of cAMP-dependent protein kinase (PKA) exists in two isoforms, RI and RII, which distinguish the PKA isozymes, type I (PKA-I) and type II (PKA-II). Evidence obtained from a variety of different experimental approaches has shown that the relative levels of type I and type II PKA in cells can play a major role in determining the balance between cell growth and differentiation. RI? transfected cells exhibit hyper-proliferative growth and RII? transfected cells revert to a relatively quiescent state. Profiling by microarray revealed equally profound changes in gene expression between RI?, RII?, and parental OVCAR cells.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12854http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12854/samples/