ArrayExpress Uploaderarrayexpress_sidhumanprimary cells from healthy donorsin vitro differentiated cells derived from CD34+ stem/progenitor cells from healthy donorsin vitro differentiated cells derived from CD34+ stem/progenitor cells from healthy donorsin vitro differentiated cells derived from CD34+ stem/progenitor cells from healthy donorsprimary cells from healthy donorsin vitro differentiated cells derived from CD34+ stem/progenitor cells from healthy donorsin vitro differentiated cells derived from CD34+ stem/progenitor cells from healthy donorsin vitro differentiated cells derived from CD34+ stem/progenitor cells from healthy donorsin vitro differentiated cells derived from CD34+ stem/progenitor cells from healthy donorsin vitro differentiated cells derived from CD34+ stem/progenitor cells from healthy donorsin vitro differentiated cells derived from CD34+ stem/progenitor cells from healthy donorsin vitro differentiated cells derived from CD34+ stem/progenitor cells from healthy donorsin vitro differentiated cells derived from CD34+ stem/progenitor cells from healthy donorsprimary cells from healthy donorsprimary cells from healthy donorsprimary cells from healthy donorsprimary cells from healthy donorsprimary cells from healthy donorsprimary cells from healthy donorsprimary cells from healthy donors147703Human myelopoiesis is an exciting biological model for cellular differentiation since it represents a plastic process where pluripotent...E-GEOD-12803/profile/8773/arrayexpressuploader120cellchromatingenomeDec.12, 2014FalseE-GEOD-12803_A-AFFY-33gene-expression-in-human-myeloid-cellsGene expression in human myeloid cellsJun.19, 2014Human myelopoiesis is an exciting biological model for cellular differentiation since it represents a plastic process where pluripotent stem cells gradually limit their differentiation potential, generating different precursor cells which finally evolve into distinct terminally differentiated cells. This study aimed at investigating the genomic expression during myeloid differentiation through a computational approach that integrates gene expression profiles with functional information and genome organization. The genomic distribution of myelopoiesis genes was investigated integrating transcriptional and functional characteristics of genes. The analysis of genomic expression during human myelopoiesis using an integrative computational approach allowed discovering important relationships between genomic position, biological function and expression patterns and highlighting chromatin domains, including genes with coordinated expression and lineage-specific functions. Keywords: cell differentiation Gene expression data from 20 experiments for 8 different cell types of the human myelopoietic lineage were used to generate an integrated myelopoiesis dataset.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12803http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12803/samples/