{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM313315 1": {}}, {"GSM313316 1": {}}, {"GSM313317 1": {}}, {"GSM313318 1": {}}, {"GSM313319 1": {}}, {"GSM313320 1": {}}, {"GSM313321 1": {}}, {"GSM313322 1": {}}, {"GSM313323 1": {}}, {"GSM313324 1": {}}], "id": 3002, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "This study was aimed at examining the effects of long-term of heat-stress on the gene expression of skeletal muscle hypertrophy. Heat-...", "geo_gse_id": "E-GEOD-12474", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 10, "tags": ["leg", "muscle", "muscular atrophy", "protein", "thigh", "vastus lateralis"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "microarray-analysis-of-skeletal-muscle-hypertrophy", "geo_id_plat": "E-GEOD-12474_A-AFFY-44", "name": "Microarray analysis of skeletal muscle hypertrophy induced by heat-stress in healthy humans", "created": "Sep.10, 2014", "summary": "This study was aimed at examining the effects of long-term of heat-stress on the gene expression of skeletal muscle hypertrophy. Heat- and stream-generating (HSG) sheets were placed on thigh laterally. The HSG sheets (heat-stress) were applied 8-hrs/day, once a day, 4 days/weeks, for 10 weeks. A muscle biopsy was taken from the vastus lateralis muscle (2 cm depth) of the treated leg before and after the experiment. Oligonucleotide microarray revealed that genes related to ATP-synthesis, protein synthesis and the molecular chaperonic activity were increased by heat stress. These results suggest that heat-stress might be a useful countermeasure for muscular atrophy during aging.  Overall design: Five subjects were applied by heat- and stream-generating (HSG) sheets for 10 weeks. Total RNAs obtained from the skeletal muscle before and after the experiment were used for the analysis.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12474", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12474/samples/"}