{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 5450, "factors": [{"GSM310386": {"STRAIN OR LINE": "C57BL/6"}}, {"GSM310386": {"STRAIN OR LINE": "C57BL/6"}}, {"GSM310386": {"STRAIN OR LINE": "C57BL/6"}}, {"GSM310386": {"STRAIN OR LINE": "C57BL/6"}}, {"GSM310392": {"STRAIN OR LINE": "C57BL/6 IFNbeta ko"}}, {"GSM310392": {"STRAIN OR LINE": "C57BL/6 IFNbeta ko"}}, {"GSM310392": {"STRAIN OR LINE": "C57BL/6 IFNbeta ko"}}, {"GSM310392": {"STRAIN OR LINE": "C57BL/6 IFNbeta ko"}}, {"GSM310397": {"STRAIN OR LINE": "C57BL/6 IFNAR ko"}}, {"GSM310397": {"STRAIN OR LINE": "C57BL/6 IFNAR ko"}}, {"GSM310397": {"STRAIN OR LINE": "C57BL/6 IFNAR ko"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Type I Interferons encompasses a large family of closely related cytokines comprising of at least 13 IFN-\u03b1 isotypes and single IFN-\u03b2....", "pubmed_id": 19581626, "geo_gse_id": "E-GEOD-12392", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 11, "tags": ["dendritic"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "influence-of-type-i-interferons-on-function-of-spl", "geo_id_plat": "E-GEOD-12392_A-AFFY-45", "name": "Influence of type I Interferons on function of splenic conventional dendritic cells.", "created": "Nov.10, 2014", "summary": "Type I Interferons encompasses a large family of closely related cytokines comprising of at least 13 IFN-\u03b1 isotypes and single IFN-\u03b2. Both IFN-\u03b1 and IFN-\u03b2 exert their activity through a common receptor IFNAR. Type I Interferons have broad regulatory effects and various subtypes of dendritic cells are influenced by this cytokines. In our study we asked question whether the low, constitutive levels of type I Interferons produced under steady state conditions are important for proper function of splenic conventional dendritic cells. In this approach we sorted out two populations (CD8\u03b1+ and CD8\u03b1-) of splenic dendritic cells (DCs) from untreated WT, IFN-\u03b2-/- and IFNAR-/- C57Bl/6 mice. All mice were between 8-10 weeks old. Further we isolated RNA and performed microarray analysis. Each DCs population was repeated twice.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12392", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12392/samples/"}