ArrayExpress Uploader05450C57BL/6C57BL/6C57BL/6C57BL/6C57BL/6 IFNbeta koC57BL/6 IFNbeta koC57BL/6 IFNbeta koC57BL/6 IFNbeta koC57BL/6 IFNAR koC57BL/6 IFNAR koC57BL/6 IFNAR koarrayexpress_sid6Type I Interferons encompasses a large family of closely related cytokines comprising of at least 13 IFN-α isotypes and single IFN-β....19581626E-GEOD-12392/profile/8773/arrayexpressuploader111dendriticDec.12, 2014Falseinfluence-of-type-i-interferons-on-function-of-splE-GEOD-12392_A-AFFY-45Influence of type I Interferons on function of splenic conventional dendritic cells.Nov.10, 2014Type I Interferons encompasses a large family of closely related cytokines comprising of at least 13 IFN-α isotypes and single IFN-β. Both IFN-α and IFN-β exert their activity through a common receptor IFNAR. Type I Interferons have broad regulatory effects and various subtypes of dendritic cells are influenced by this cytokines. In our study we asked question whether the low, constitutive levels of type I Interferons produced under steady state conditions are important for proper function of splenic conventional dendritic cells. In this approach we sorted out two populations (CD8α+ and CD8α-) of splenic dendritic cells (DCs) from untreated WT, IFN-β-/- and IFNAR-/- C57Bl/6 mice. All mice were between 8-10 weeks old. Further we isolated RNA and performed microarray analysis. Each DCs population was repeated twice.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12392mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12392/samples/