ArrayExpress Uploader08364arrayexpress_sid8We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute...18977325E-GEOD-12310/profile/8773/arrayexpressuploader039bonebone marrowDec.12, 2014Falsetranscription-profiling-of-mouse-normal-lymphoid-pE-GEOD-12310_A-AFFY-36Transcription profiling of mouse normal lymphoid progenitors and MLL-AF4 leukemic lymphoblastsNov.24, 2014We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Immunophenotypic and gene expression analysis of the ALL cells demonstrated bone marrow replacement with B-precursor cells which express a gene expression profile that has significant overlap with profiles in human MLL-rearranged ALL. Experiment Overall Design: Total RNA from normal pro-B, pre-B, immature B and mature B lymphocytes, and from leukemic pre-B cells was isolated and hybridized to Affymetrix expresison microarrays.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12310mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12310/samples/