4ArrayExpress Uploader0humanresponse to Infliximab treatmentno response to Infliximabresponse to Infliximab treatmentresponse to Infliximab treatmentresponse to Infliximab treatmentno response to Infliximabno response to Infliximabno response to Infliximabresponse to Infliximab treatmentresponse to Infliximab treatmentresponse to Infliximab treatmentresponse to Infliximab treatmentno response to Infliximabresponse to Infliximab treatmentresponse to Infliximab treatmentno response to Infliximabno response to Infliximabno response to Infliximabno response to Infliximabno response to Infliximabresponse to Infliximab treatmentresponse to Infliximab treatmentno response to Infliximab2980arrayexpress_sidhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12251Infliximab, an anti-TNFa monoclonal antibody, is an effective treatment for ulcerative colitis (UC) inducing over 60% of patients to...19700435/profile/8773/arrayexpressuploader123colitisulcerative colitisDec.12, 2014Falsetranscription-profiling-by-array-of-human-ulceratiE-GEOD-12251_A-AFFY-44Transcription profiling by array of human ulcerative colitis samples with varying responses to infliximabSep.10, 2014Infliximab, an anti-TNFa monoclonal antibody, is an effective treatment for ulcerative colitis (UC) inducing over 60% of patients to respond to treatment. Consequently, about 40% of patients do not respond. This study analyzed mucosal gene expression from patients enrolled in ACT1 to provide a predictive response signature for infliximab treatment. Experiment Overall Design: Twenty-two patients underwent colonoscopy with biopsy before infliximab treatment. Response to infliximab was defined as endoscopic and histologic healing at week 8 (P2, 5, 9, 10, 14, 15, 16, 17, 24, 27, 36, and 45 as responders; P3, 12, 13, 19, 28, 29, 32, 33, 34, and 47 as non-responders). Messenger RNA was isolated from pre-infliximab biopsies, labeled and hybridized to Affymetrix HGU133Plus_2.0 Array. The predictive response signature was verified by an independent data set.E-GEOD-12251http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12251/samples/