{"platform": 4, "owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSE12251GSM307886": {"clinical information": "response to Infliximab treatment"}}, {"GSE12251GSM307887": {"clinical information": "no response to Infliximab"}}, {"GSE12251GSM307886": {"clinical information": "response to Infliximab treatment"}}, {"GSE12251GSM307886": {"clinical information": "response to Infliximab treatment"}}, {"GSE12251GSM307886": {"clinical information": "response to Infliximab treatment"}}, {"GSE12251GSM307887": {"clinical information": "no response to Infliximab"}}, {"GSE12251GSM307887": {"clinical information": "no response to Infliximab"}}, {"GSE12251GSM307887": {"clinical information": "no response to Infliximab"}}, {"GSE12251GSM307886": {"clinical information": "response to Infliximab treatment"}}, {"GSE12251GSM307886": {"clinical information": "response to Infliximab treatment"}}, {"GSE12251GSM307886": {"clinical information": "response to Infliximab treatment"}}, {"GSE12251GSM307886": {"clinical information": "response to Infliximab treatment"}}, {"GSE12251GSM307887": {"clinical information": "no response to Infliximab"}}, {"GSE12251GSM307886": {"clinical information": "response to Infliximab treatment"}}, {"GSE12251GSM307886": {"clinical information": "response to Infliximab treatment"}}, {"GSE12251GSM307887": {"clinical information": "no response to Infliximab"}}, {"GSE12251GSM307887": {"clinical information": "no response to Infliximab"}}, {"GSE12251GSM307887": {"clinical information": "no response to Infliximab"}}, {"GSE12251GSM307887": {"clinical information": "no response to Infliximab"}}, {"GSE12251GSM307887": {"clinical information": "no response to Infliximab"}}, {"GSE12251GSM307886": {"clinical information": "response to Infliximab treatment"}}, {"GSE12251GSM307886": {"clinical information": "response to Infliximab treatment"}}, {"GSE12251GSM307887": {"clinical information": "no response to Infliximab"}}], "id": 2980, "ownerprofile_id": "arrayexpress_sid", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12251", "summary_wrapped": "Infliximab, an anti-TNFa monoclonal antibody, is an effective treatment for ulcerative colitis (UC) inducing over 60% of patients to...", "pubmed_id": 19700435, "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 23, "tags": ["colitis", "ulcerative colitis"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-by-array-of-human-ulcerati", "geo_id_plat": "E-GEOD-12251_A-AFFY-44", "name": "Transcription profiling by array of human ulcerative colitis samples with varying responses to infliximab", "created": "Sep.10, 2014", "summary": "Infliximab, an anti-TNFa monoclonal antibody, is an effective treatment for ulcerative colitis (UC) inducing over 60% of patients to respond to treatment. Consequently, about 40% of patients do not respond. This study analyzed mucosal gene expression from patients enrolled in ACT1 to provide a predictive response signature for infliximab treatment. Experiment Overall Design: Twenty-two patients underwent colonoscopy with biopsy before infliximab treatment. Response to infliximab was defined as endoscopic and histologic healing at week 8 (P2, 5, 9, 10, 14, 15, 16, 17, 24, 27, 36, and 45 as responders; P3, 12, 13, 19, 28, 29, 32, 33, 34, and 47 as non-responders). Messenger RNA was isolated from pre-infliximab biopsies, labeled and hybridized to Affymetrix HGU133Plus_2.0 Array. The predictive response signature was verified by an independent data set.", "geo_gse_id": "E-GEOD-12251", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12251/samples/"}