{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 2975, "factors": [{"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306735": {"disease state": "mild chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306733": {"disease state": "severe chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}, {"GSE12187GSM306736": {"disease state": "moderate chronic allograft nephropathy"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Despite significant improvements in life expectancy of kidney transplant patients due to advances in surgery and immunosuppression,...", "pubmed_id": 19593431, "geo_gse_id": "E-GEOD-12187", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 77, "tags": ["kidney", "peripheral"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-of-human-blood-from-kidney", "geo_id_plat": "E-GEOD-12187_A-AFFY-44", "name": "Transcription profiling of human blood from kidney transplant patients to identify biomarkers for early and late stage chronic allograft nephropathy by genomic profiling", "created": "Sep.10, 2014", "summary": "Despite significant improvements in life expectancy of kidney transplant patients due to advances in surgery and immunosuppression, Chronic Allograft Nephropathy (CAN) remains a daunting problem. A complex network of cellular mechanisms in both graft and peripheral immune compartments complicates the non-invasive diagnosis of CAN, which still requires biopsy histology. This is compounded by non-immunological factors contributing to graft injury.  There is a pressing need to identify and validate minimally invasive biomarkers for CAN to serve as early predictors of graft loss and as metrics for managing long-term immunosuppression. This study attempts to identify sets of unique transcript biomarkers with high predictive accuracy for both mild and moderate/severe CAN. These biomarkers are the necessary first step to a genomic classification of CAN based on peripheral blood and the targets for a prospective, serial-monitoring clinical study. Experiment Overall Design: We used DNA microarrays and bioinformatics to identify candidate genomic markers of mild and moderate/severe CAN in peripheral blood of two distinct cohorts (n=42 and n=35, respectively) of kidney transplant patients with biopsy-documented histology.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12187", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12187/samples/"}