{"platform": 6, "owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "id": 5441, "factors": [{"GSE12134GSM305788": {}}, {"GSE12134GSM305861": {}}, {"GSE12134GSM305862": {}}, {"GSE12134GSM305863": {}}, {"GSE12134GSM305864": {}}, {"GSE12134GSM305865": {}}, {"GSE12134GSM305866": {}}, {"GSE12134GSM305867": {}}, {"GSE12134GSM305868": {}}, {"GSE12134GSM305869": {}}, {"GSE12134GSM305870": {}}, {"GSE12134GSM305871": {}}], "pop_total": 0, "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12134", "summary_wrapped": "Understanding the mechanisms that specify neuronal subtypes is important to unravel the complex mechanisms of neuronal circuit assembly....", "pubmed_id": 19749747, "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 12, "tags": ["basal", "caudal", "cerebral cortex", "cortex", "rostral"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-12134_A-AFFY-45", "slug": "transcription-profiling-of-mouse-cortex-rostral-an", "geo_gds_id": "", "name": "Transcription profiling of mouse cortex (rostral and caudal) of AP2gamma knockouts  and control mic revels transcription factor AP2I? regulates the number of basal progenitors", "created": "Nov.10, 2014", "summary": "Understanding the mechanisms that specify neuronal subtypes is important to unravel the complex mechanisms of neuronal circuit assembly. Here we have identified a novel role for the transcription factor AP2\u03b3 in progenitor and neuronal subtype specification in the cerebral cortex. Conditional deletion of AP2\u03b3 causes misspecification of basal progenitors starting at; mid-neurogenesis and gain-of-function experiments show that AP2\u03b3 directly regulates the expression of several genes characteristic for basal progenitors, such as Math3 and Tbr2. The misspecification of basal progenitors upon loss of AP2\u03b3 resulted in their increased death and; the ultimate reduction of callosal layer II/III projection neurons. This had pronounced effects on visual performance with a strong reduction of visual acuity. Thus, we have identified a novel regulator of basal progenitor fate regulating the number of layer II/III neurons in an area-specific manner and revealing their importance for accurate function of the visual cortex. Experiment Overall Design: We analysed 12 samples from the cortex (rostral and caudal) of AP2gamma k.o. mice and control mice. For each of the 4 groups (caudal ko, caudal wt, rostral ko, rostral wt) three biological replicates were analysed.", "geo_gse_id": "E-GEOD-12134", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-12134/samples/"}