{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSE11726GSM297572": {}}, {"GSE11726GSM297575": {}}, {"GSE11726GSM297573": {}}, {"GSE11726GSM297577": {}}, {"GSE11726GSM297574": {}}, {"GSE11726GSM297579": {}}], "id": 8356, "ownerprofile_id": "arrayexpress_sid", "platform": 8, "summary_wrapped": "We analyzed whether cochlear removal-induced transcriptional changes in the cochlear nucleus (CN) were due to loss of electrical activity...", "geo_gse_id": "E-GEOD-11726", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 6, "tags": ["cochlea", "cochlear nucleus", "nerve"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-11726_A-AFFY-36", "slug": "transcription-profiling-of-mouse-p21-cochlear-nucl", "geo_gds_id": "", "name": "Transcription profiling of mouse P21 cochlear nucleus after activity deprivation", "created": "Nov.24, 2014", "summary": "We analyzed whether cochlear removal-induced transcriptional changes in the cochlear nucleus (CN) were due to loss of electrical activity in the 8th nerve.  Pharmacological activity blockade of the auditory nerve for 24 h resulted in similar expression changes for only a subset of genes.  Thus, an additional factor not dependent on action potential-mediated signaling must also regulate transcriptional responses to deafferentation in the CN.   Experiment Overall Design: TTX was infused into the cochlea unilaterally via osmotic pumps to block activity in the 8th nerve.  CN tissue was dissected out from 10-12 mice per replicate and pooled.  Three biological replicates were performed.  Gene expression was compared between the ipsilateral and contralateral CN tissue to identify genes transcriptionally regulated after activity deprivation.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-11726", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-11726/samples/"}