ArrayExpress Uploader0mouse5405arrayexpress_sid6Matriptase-2 (Tmprss6), a recently described member of the TTSP family, is an essential regulator of iron homeostasis. Tmprss6-/- mice...E-GEOD-11632/profile/8773/arrayexpressuploader02alopeciaanemiadeficiency anemiairon deficiency anemialiverDec.12, 2014FalseE-GEOD-11632_A-AFFY-45transcription-profiling-of-mouse-liver-from-tmprssTranscription profiling of mouse liver from Tmprss6-deficient animalNov.10, 2014Matriptase-2 (Tmprss6), a recently described member of the TTSP family, is an essential regulator of iron homeostasis. Tmprss6-/- mice display an overt phenotype of alopecia and a severe iron deficiency anemia. These hematological alterations found in Tmprss6-/- mice are accompanied by a marked up-regulation of hepcidin, a negative regulator of iron export into plasma. Experiment Overall Design: Tmprss6-deficient mice were generated by gene targeting. Total RNA was extracted from liver samples from control and Tmprss6-deficient male mice after o/n fasting. Transcriptional profiling was analyzed using GeneChip Mouse 430 2.0 arrays.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-11632http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-11632/samples/