{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSE11632GSM294994": {}}, {"GSE11632GSM294995": {}}], "id": 5405, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Matriptase-2 (Tmprss6), a recently described member of the TTSP family, is an essential regulator of iron homeostasis. Tmprss6-/- mice...", "geo_gse_id": "E-GEOD-11632", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 2, "tags": ["alopecia", "anemia", "deficiency anemia", "iron deficiency anemia", "liver"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-11632_A-AFFY-45", "slug": "transcription-profiling-of-mouse-liver-from-tmprss", "geo_gds_id": "", "name": "Transcription profiling of mouse liver from Tmprss6-deficient animal", "created": "Nov.10, 2014", "summary": "Matriptase-2 (Tmprss6), a recently described member of the TTSP family, is an essential regulator of iron homeostasis. Tmprss6-/- mice display an overt phenotype of alopecia and a severe iron deficiency anemia. These hematological alterations found in Tmprss6-/- mice are accompanied by a marked up-regulation of hepcidin, a negative regulator of iron export into plasma.  Experiment Overall Design: Tmprss6-deficient mice were generated by gene targeting. Total RNA was extracted from liver samples from control and Tmprss6-deficient male mice after o/n fasting. Transcriptional profiling was analyzed using GeneChip Mouse 430 2.0 arrays.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-11632", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-11632/samples/"}