{"platform": 4, "owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSE11324GSM286031": {"dose": "    ", "time": "  ", "compound": "none"}}, {"GSE11324GSM286031": {"dose": "    ", "time": "  ", "compound": "none"}}, {"GSE11324GSM286031": {"dose": "    ", "time": "  ", "compound": "none"}}, {"GSE11324GSM286040": {"dose": "100", "time": "12", "compound": "estrogen"}}, {"GSE11324GSM286040": {"dose": "100", "time": "12", "compound": "estrogen"}}, {"GSE11324GSM286040": {"dose": "100", "time": "12", "compound": "estrogen"}}, {"GSE11324GSM286034": {"dose": "100", "time": "3", "compound": "estrogen"}}, {"GSE11324GSM286034": {"dose": "100", "time": "3", "compound": "estrogen"}}, {"GSE11324GSM286034": {"dose": "100", "time": "3", "compound": "estrogen"}}, {"GSE11324GSM286037": {"dose": "100", "time": "6", "compound": "estrogen"}}, {"GSE11324GSM286037": {"dose": "100", "time": "6", "compound": "estrogen"}}, {"GSE11324GSM286037": {"dose": "100", "time": "6", "compound": "estrogen"}}], "id": 2859, "ownerprofile_id": "arrayexpress_sid", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-11324", "summary_wrapped": "The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic...", "pubmed_id": 17013392, "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 12, "tags": ["breast", "breast cancer", "cancer", "estrogen", "genome"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-by-array-of-human-mcf-cell", "geo_id_plat": "E-GEOD-11324_A-AFFY-44", "name": "Transcription profiling by array of human MCF cells treated with estrogen", "created": "Sep.03, 2014", "summary": "The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells.  Combining this unique resource with gene expression data demonstrates distinct temporal mechanisms of estrogen-mediated gene regulation,particularly in the case of estrogen-suppressed genes.  Furthermore, this resource has allowed the identification of cis-regulatory sites in previously unexplored regions of the genome and the cooperating transcription factors underlying estrogen signaling in breast cancer. Experiment Overall Design: This Series currently contains the gene expression data accompaning Carroll JS et al. Nature Genetics 38,1289-1297(2006).  MCF7 cells were stimulated with 100 nM estrogen for 0, 3, 6, or 12h.  All experiments were performed in triplicate.", "geo_gse_id": "E-GEOD-11324", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-11324/samples/"}