ArrayExpress Uploaderarrayexpress_sidmouse537506Loss of Rb family in HSCs results in a severe phenotype, such as enhanced proliferation and increase in stem cell number. In addition,...E-GEOD-11253/profile/8773/arrayexpressuploader05cellcompartmentdiseasemyeloproliferative diseasestem cellDec.12, 2014Falsetranscription-profiling-of-mouse-rb-p130-and-p107E-GEOD-11253_A-AFFY-45Transcription profiling of mouse Rb, p130 and p107 deficient hematopoietic stem CellsNov.10, 2014Loss of Rb family in HSCs results in a severe phenotype, such as enhanced proliferation and increase in stem cell number. In addition, HSCs were higly mobilized but failed to transplant. Rb family deficient mice rapidly exhibit a myeloproliferative disease with eosinophilic characteristics. Meanwhile, the lymphoid compartment was severely decreased, due to high apoptotic activity in this lineage. Experiment Overall Design: We used mice that harbor floxed alleles for the Rb family and we induced the recombination by 6 weeks of age. KLS (c-Kit+ Lin - Sca-1+) cells were sorted 2 months after the recombination. Experiment Overall Design: Total of 6 hybridizations done. One Sample was excluded from our analysis based on high background and anomalous control probeset values.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-11253http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-11253/samples/