{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSE11253GSM284096": {}}, {"GSE11253GSM284097": {}}, {"GSE11253GSM284098": {}}, {"GSE11253GSM284094": {}}, {"GSE11253GSM284095": {}}], "id": 5375, "pop_total": 0, "platform": 6, "summary_wrapped": "Loss of Rb family in HSCs results in a severe phenotype, such as enhanced proliferation and increase in stem cell number. In addition,...", "geo_gse_id": "E-GEOD-11253", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 5, "tags": ["cell", "compartment", "disease", "myeloproliferative disease", "stem cell"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-of-mouse-rb-p130-and-p107", "geo_id_plat": "E-GEOD-11253_A-AFFY-45", "name": "Transcription profiling of mouse Rb, p130 and p107 deficient hematopoietic stem Cells", "created": "Nov.10, 2014", "summary": "Loss of Rb family in HSCs results in a severe phenotype, such as enhanced proliferation and increase in stem cell number. In addition, HSCs were higly mobilized but failed to transplant. Rb family deficient mice rapidly exhibit a myeloproliferative disease with eosinophilic characteristics. Meanwhile, the lymphoid compartment was severely decreased, due to high apoptotic activity in this lineage. Experiment Overall Design: We used mice that harbor floxed alleles for the Rb family and we induced the recombination by 6 weeks of age. KLS (c-Kit+ Lin - Sca-1+) cells were sorted 2 months after the recombination. Experiment Overall Design: Total of 6 hybridizations done.  One Sample was excluded from our analysis based on high background and anomalous control probeset values.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-11253", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-11253/samples/"}