{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 5340, "factors": [{"GSM272995 1": {}}, {"GSM272996 1": {}}, {"GSM272997 1": {}}, {"GSM272998 1": {}}, {"GSM272999 1": {}}, {"GSM273000 1": {}}, {"GSM273001 1": {}}, {"GSM273002 1": {}}, {"GSM273003 1": {}}, {"GSM273004 1": {}}, {"GSM273005 1": {}}, {"GSM273006 1": {}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "CD8+ NKT cells are naturally occurring but rare T cells that express both T cell and natural killer (NK) cell markers.  These cells may...", "pubmed_id": 18664279, "geo_gse_id": "E-GEOD-10813", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 12, "tags": ["cell"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "the-in-vitro-expanded-cd8-t-cells-and-its-controls", "geo_id_plat": "E-GEOD-10813_A-AFFY-45", "name": "The in vitro expanded CD8+ T cells and its controls", "created": "Nov.10, 2014", "summary": "CD8+ NKT cells are naturally occurring but rare T cells that express both T cell and natural killer (NK) cell markers.  These cells may play key roles in establishing tolerance to self antigens; however, the mechanism of action and the molecular profiles of these cells are poorly characterized due to their extremely low frequencies.  We developed a highly efficient in vitro conversion/expansion protocol for such cells and extensively characterized their functional and molecular phenotypes using a variety of genomic and immunological techniques. We used microarrays to elucidate the molecular mechanisms underlying the suppression function of the converted CD8+ NKT cells. Keywords: Cell type comparison To identify candidate genes that might be related to the suppressive activity, the CD8+ NKT cells with potent suppressive activity were compared to three different control cells: 1) CD4+ T cells (with very weak suppression) cultured under the same condition as a control for culture condition, 2) na\u00efve CD8 T cells as the baseline expression level, and 3) CD8+ T cells activated using conventional activation protocols.  The last two cell populations do not possess suppressive activity.  This data set allows us to examine a number of different questions", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-10813", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-10813/samples/"}