ArrayExpress Uploaderarrayexpress_sidmouse533306IL-1R-associated kinases (IRAKs) participate in Toll-like receptor (TLR) signal transduction. MALP-2 is a TLR2 ligand, and stimulation of...E-GEOD-10765/profile/8773/arrayexpressuploader012Dec.12, 2014Falsetranscription-profiling-of-mouse-malp-2-stimulatedE-GEOD-10765_A-AFFY-45Transcription profiling of mouse MALP-2-stimulated macrophages FROM wild-TYPE, IRAK-2-/- AND IRAK-1-/IRAK-2-/- animalsNov.10, 2014IL-1R-associated kinases (IRAKs) participate in Toll-like receptor (TLR) signal transduction. MALP-2 is a TLR2 ligand, and stimulation of macrophages with MALP-2 activates expression of various genes including proinflammatory cytokines. We used microarrays to examine influence of IRAK-2 or IRAK-1/IRAK-2 deficiency in MALP-2-inducible gene expression. Experiment Overall Design: Peritoneal macrophages from wild-type, IRAK-2-/- and IRAK-1/IRAK-2 mice were stimulated with MALP-2 for 0, 2, 4, and 8 hours, followed by RNA extraction. Then hybridization on affymetrix microarrays was performed.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-10765http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-10765/samples/