ArrayExpress Uploader08220110 nM 2,3,7,8-Tetrachlorodibenzo-p-dioxinThymus emigrants2Dioxane 2thymus110 nM 2,3,7,8-Tetrachlorodibenzo-p-dioxinthymus210 nM 2,3,7,8-Tetrachlorodibenzo-p-dioxinThymus Emigrants1Corn Oilthymus2Corn oilthymus110 nM 2,3,7,8-Tetrachlorodibenzo-p-dioxinthymus210 nM 2,3,7,8-Tetrachlorodibenzo-p-dioxinthymusarrayexpress_sid7Over-activation of the aryl hydrocarbon receptor by TCDD in mice leads among other phenotypes to a severe thymic atrophy accompanied by...16114106E-GEOD-10166/profile/8773/arrayexpressuploader38spleenthymocytethymusDec.12, 2014Falserole-of-ahr-in-thymocyte-emigration-in-vivoE-GEOD-10166_A-AFFY-23Role of AhR in thymocyte emigration in vivoNov.23, 2014Over-activation of the aryl hydrocarbon receptor by TCDD in mice leads among other phenotypes to a severe thymic atrophy accompanied by immunosuppression. TCDD causes a block in thymocyte maturation and a preferential emigration of immature CD4-CD8- DN thymocytes (recent thymic emigrants) into the periphery. As part of this study gene expression profiles from DN thymocytes and thymic emigrants were generated from TCDD and solvent control mice Keywords: Affymetrix, TCDD, CD4-CD8- thymocytes, Thymus involution, thymic emigration, Ahr Female, 6-8 week old C57BL6 mice were i.p. injected with 10 µg/kg TCDD. After 5 days mice were anesthezised and FITC injected into their thymi. after 24h mice were sacrificed and CD4-CD8-FITC+ cells isolated from thymus (thymocytes) and spleen (recent thymus emigrants).http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-10166mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-10166/samples/