{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 8220, "factors": [{"GSM256739": {"REPLICATE": 1, "TREATMENT": "10 nM 2,3,7,8-Tetrachlorodibenzo-p-dioxin", "ORGANISM PART": "Thymus emigrants"}}, {"GSM25674": {"REPLICATE": 2, "TREATMENT": "Dioxane 2", "ORGANISM PART": "thymus"}}, {"GSM256743": {"REPLICATE": 1, "TREATMENT": "10 nM 2,3,7,8-Tetrachlorodibenzo-p-dioxin", "ORGANISM PART": "thymus"}}, {"GSM256744": {"REPLICATE": 2, "TREATMENT": "10 nM 2,3,7,8-Tetrachlorodibenzo-p-dioxin", "ORGANISM PART": "Thymus Emigrants"}}, {"GSM256979": {"REPLICATE": 1, "TREATMENT": "Corn Oil", "ORGANISM PART": "thymus"}}, {"GSM256980": {"REPLICATE": 2, "TREATMENT": "Corn oil", "ORGANISM PART": "thymus"}}, {"GSM256743": {"REPLICATE": 1, "TREATMENT": "10 nM 2,3,7,8-Tetrachlorodibenzo-p-dioxin", "ORGANISM PART": "thymus"}}, {"GSM256982": {"REPLICATE": 2, "TREATMENT": "10 nM 2,3,7,8-Tetrachlorodibenzo-p-dioxin", "ORGANISM PART": "thymus"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 7, "summary_wrapped": "Over-activation of the aryl hydrocarbon receptor by TCDD in mice leads among other phenotypes to a severe thymic atrophy accompanied by...", "pubmed_id": 16114106, "geo_gse_id": "E-GEOD-10166", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 8, "tags": ["spleen", "thymocyte", "thymus"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "role-of-ahr-in-thymocyte-emigration-in-vivo", "geo_id_plat": "E-GEOD-10166_A-AFFY-23", "name": "Role of AhR in thymocyte emigration in vivo", "created": "Nov.23, 2014", "summary": "Over-activation of the aryl hydrocarbon receptor by TCDD in mice leads among other phenotypes to a severe thymic atrophy accompanied by immunosuppression. TCDD causes a block in thymocyte maturation and a preferential emigration of immature CD4-CD8- DN thymocytes (recent thymic emigrants) into the periphery. As part of this study gene expression profiles from DN thymocytes and thymic emigrants were generated from TCDD and solvent control mice Keywords: Affymetrix, TCDD, CD4-CD8- thymocytes, Thymus involution, thymic emigration, Ahr Female, 6-8 week old C57BL6 mice were i.p. injected with 10 \u00b5g/kg TCDD. After 5 days mice were anesthezised and FITC injected into their thymi. after 24h mice were sacrificed and CD4-CD8-FITC+ cells isolated from thymus (thymocytes) and spleen (recent thymus emigrants).", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-10166", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-10166/samples/"}