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Home › Dataset Library › The Complex Exogenous RNA Spectra in Human Plasma: An Interface with Human Gut Biota?

Dataset: The Complex Exogenous RNA Spectra in Human Plasma: An Interface with Human Gut Biota?

Human plasma has long been a rich source for biomarker discovery. It has recently become clear that plasma RNA molecules, such as...

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Human plasma has long been a rich source for biomarker discovery. It has recently become clear that plasma RNA molecules, such as microRNA, in addition to proteins are common and can serve as biomarkers. Surveying human plasma for microRNA biomarkers using next generation sequencing technology, we observed that a significant fraction of the circulating RNA appear to originate from exogenous species. With careful analysis of sequence error statistics and other controls, we demonstrated that there is a wide range of RNA from many different organisms, including bacteria and fungi as well as from other species. These RNAs may be associated with protein, lipid or other molecules protecting them from RNase activity in plasma. Some of these RNAs are detected in intracellular complexes and may be able to influence cellular activities under in vitro conditions. These findings raise the possibility that plasma RNAs of exogenous origin may serve as signaling molecules mediating for example the human-microbiome interaction and may affect and/or indicate the state of human health.

Species:
human

Samples:
9

PubMed:
23251414

Updated:
Jul.30, 2018

Registered:
Jul.30, 2018


Factors:
Sample trancriptome_genome-ratio cell_culture_source related_dataset_id fastq_identifier anatomical_location biosample_metadata_id exRNA_source transcriptome_reads reference_genome_reads biofluid_name RNA_isolation_kit profiling_assay meets_ERCC_QC species condition
D3142P 0.460801 Not Applicable EXR-DGALA1V5h5va-AN sample_SM11_norm1_sequence_fastq Entire cardiovascular system EXR-DGALA1D3142PFN-BS total cell-free biofluid RNA 230,891 501,064 Plasma miRNeasy (Qiagen) small RNA-Seq NO Human Healthy Control
D3176P 0.357747 Not Applicable EXR-DGALA1V5h5va-AN sample_SM12_norm2_sequence_fastq Entire cardiovascular system EXR-DGALA1D3176PFN-BS total cell-free biofluid RNA 142,222 397,549 Plasma miRNeasy (Qiagen) small RNA-Seq NO Human Healthy Control
D3340P 0.382272 Not Applicable EXR-DGALA1V5h5va-AN sample_SM13_norm3_sequence_fastq Entire cardiovascular system EXR-DGALA1D3340PMN-BS total cell-free biofluid RNA 155,011 405,499 Plasma miRNeasy (Qiagen) small RNA-Seq NO Human Healthy Control
022163P 0.33314 Not Applicable EXR-DGALA1V5h5va-AN sample_SM1_crc1_sequence_fastq Entire cardiovascular system EXR-DGALA1022163PF-BS total cell-free biofluid RNA 29,923 89,821 Plasma miRNeasy (Qiagen) small RNA-Seq NO Human colorectal cancer
022273P 0.418862 Not Applicable EXR-DGALA1V5h5va-AN sample_SM2_crc2_sequence_fastq Entire cardiovascular system EXR-DGALA1022273PF-BS total cell-free biofluid RNA 80,212 191,500 Plasma miRNeasy (Qiagen) small RNA-Seq NO Human colorectal cancer
022299P 0.379583 Not Applicable EXR-DGALA1V5h5va-AN sample_SM3_crc3_sequence_fastq Entire cardiovascular system EXR-DGALA1022299PM-BS total cell-free biofluid RNA 88,709 233,701 Plasma miRNeasy (Qiagen) small RNA-Seq NO Human colorectal cancer
93163P 0.285972 Not Applicable EXR-DGALA1V5h5va-AN sample_SM6_uc1_sequence_fastq Entire cardiovascular system EXR-DGALA193163PMC-BS total cell-free biofluid RNA 52,249 182,707 Plasma miRNeasy (Qiagen) small RNA-Seq NO Human Ulcerative Colitis
93164P 0.268383 Not Applicable EXR-DGALA1V5h5va-AN sample_SM7_uc2_sequence_fastq Entire cardiovascular system EXR-DGALA193164PMC-BS total cell-free biofluid RNA 50,522 188,246 Plasma miRNeasy (Qiagen) small RNA-Seq NO Human Ulcerative Colitis
93166P 0.516342 Not Applicable EXR-DGALA1V5h5va-AN sample_SM8_uc3_sequence_fastq Entire cardiovascular system EXR-DGALA193166PFC-BS total cell-free biofluid RNA 199,026 385,454 Plasma miRNeasy (Qiagen) small RNA-Seq YES Human Ulcerative Colitis

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