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{"trancriptome_genome-ratio": "0.864368", "transcriptome_reads": "3,281,101", "related_dataset_id": "EXR-SADAS1EXER1-AN", "fastq_identifier": "sample_Sample_030_EX_PK_GACGAC_R1_001_fastq", "biosample_metadata_id": "EXR-SADAS1Ex3002-BS", "exRNA_source": "total cell-free biofluid RNA", "cell_culture_source": "Not Applicable", "species": "Human", "anatomical_location": "Entire body system", "RNA_isolation_kit": "MiRVana Paris (Ambion)", "profiling_assay": "small RNA-Seq", "meets_ERCC_QC": "YES", "reference_genome_reads": "3,795,956", "condition": "Healthy Control", "biofluid_name": "Plasma"}}, {"031_EX_BL_GTCCGC": {"trancriptome_genome-ratio": "0.955371", "transcriptome_reads": "4,536,552", "related_dataset_id": "EXR-SADAS1EXER1-AN", "fastq_identifier": "sample_Sample_031_EX_BL_GTCCGC_R1_001_fastq", "biosample_metadata_id": "EXR-SADAS1Ex3101-BS", "exRNA_source": "total cell-free biofluid RNA", "cell_culture_source": "Not Applicable", "species": "Human", "anatomical_location": "Entire body 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"sample_Sample_068_BL_Vs_CGATGT_combined_2_R1_001_fastq", "biosample_metadata_id": "EXR-SADAS1Ex6801-BS", "exRNA_source": "extracellular vesicle", "cell_culture_source": "Not Applicable", "species": "Human", "anatomical_location": "Entire body system", "RNA_isolation_kit": "MiRVana Paris (Ambion)", "profiling_assay": "small RNA-Seq", "meets_ERCC_QC": "NO", "reference_genome_reads": "1,618,341", "condition": "Healthy Control", "biofluid_name": "Plasma"}}, {"068_Ex_BL_CTTGTA": {"trancriptome_genome-ratio": "0.995714", "transcriptome_reads": "10,070,795", "related_dataset_id": "EXR-SADAS1EXER1-AN", "fastq_identifier": "sample_Sample_068_Ex_BL_CTTGTA_R1_001_fastq", "biosample_metadata_id": "EXR-SADAS1Ex6802-BS", "exRNA_source": "total cell-free biofluid RNA", "cell_culture_source": "Not Applicable", "species": "Human", "anatomical_location": "Entire body system", "RNA_isolation_kit": "MiRVana Paris (Ambion)", "profiling_assay": "small RNA-Seq", "meets_ERCC_QC": "YES", "reference_genome_reads": "10,114,141", "condition": "Healthy Control", "biofluid_name": "Plasma"}}, {"068_Ex_PK_GTAGAG": {"trancriptome_genome-ratio": "0.942621", "transcriptome_reads": "1,590,435", "related_dataset_id": "EXR-SADAS1EXER1-AN", "fastq_identifier": "sample_Sample_068_Ex_PK_GTAGAG_R1_001_fastq", "biosample_metadata_id": "EXR-SADAS1Ex6803-BS", "exRNA_source": "total cell-free biofluid RNA", "cell_culture_source": "Not Applicable", "species": "Human", "anatomical_location": "Entire body system", "RNA_isolation_kit": "MiRVana Paris (Ambion)", "profiling_assay": "small RNA-Seq", "meets_ERCC_QC": "YES", "reference_genome_reads": "1,687,248", "condition": "Healthy Control", "biofluid_name": "Plasma"}}, {"068_PK_Vs_CAGATC": {"trancriptome_genome-ratio": "0.469104", "transcriptome_reads": "199,597", "related_dataset_id": "EXR-SADAS1EXER1-AN", "fastq_identifier": "sample_Sample_068_PK_Vs_CAGATC_R1_001_fastq", "biosample_metadata_id": "EXR-SADAS1Ex6804-BS", "exRNA_source": "extracellular vesicle", "cell_culture_source": "Not Applicable", "species": "Human", "anatomical_location": "Entire body system", "RNA_isolation_kit": "MiRVana Paris (Ambion)", "profiling_assay": "small RNA-Seq", "meets_ERCC_QC": "NO", "reference_genome_reads": "425,486", "condition": "Healthy Control", "biofluid_name": "Plasma"}}, {"070_BL_Vs_TTAGGC": {"trancriptome_genome-ratio": "0.844106", "transcriptome_reads": "2,414,319", "related_dataset_id": "EXR-SADAS1EXER1-AN", "fastq_identifier": "sample_Sample_070_BL_Vs_TTAGGC_R1_001_fastq", "biosample_metadata_id": "EXR-SADAS1Ex7001-BS", "exRNA_source": "extracellular vesicle", "cell_culture_source": "Not Applicable", "species": "Human", "anatomical_location": "Entire body system", "RNA_isolation_kit": "MiRVana Paris (Ambion)", "profiling_assay": "small RNA-Seq", "meets_ERCC_QC": "YES", "reference_genome_reads": "2,860,210", "condition": "Healthy Control", "biofluid_name": "Plasma"}}, {"070_Ex_BL_AGTCAA": {"trancriptome_genome-ratio": "0.980084", "transcriptome_reads": "6,399,067", "related_dataset_id": "EXR-SADAS1EXER1-AN", "fastq_identifier": "sample_Sample_070_Ex_BL_AGTCAA_R1_001_fastq", "biosample_metadata_id": "EXR-SADAS1Ex7002-BS", "exRNA_source": "total cell-free biofluid RNA", "cell_culture_source": "Not Applicable", "species": "Human", "anatomical_location": "Entire body system", "RNA_isolation_kit": "MiRVana Paris (Ambion)", "profiling_assay": "small RNA-Seq", "meets_ERCC_QC": "YES", "reference_genome_reads": "6,529,102", "condition": "Healthy Control", "biofluid_name": "Plasma"}}, {"070_Ex_PK_GTCCGC": {"trancriptome_genome-ratio": "0.973877", "transcriptome_reads": "1,974,718", "related_dataset_id": "EXR-SADAS1EXER1-AN", "fastq_identifier": "sample_Sample_070_Ex_PK_GTCCGC_R1_001_fastq", "biosample_metadata_id": "EXR-SADAS1Ex7003-BS", "exRNA_source": "total cell-free biofluid RNA", "cell_culture_source": "Not Applicable", "species": "Human", "anatomical_location": "Entire body system", "RNA_isolation_kit": "MiRVana Paris (Ambion)", "profiling_assay": "small RNA-Seq", "meets_ERCC_QC": "YES", "reference_genome_reads": "2,027,688", "condition": "Healthy Control", "biofluid_name": "Plasma"}}, {"070_PK_Vs_ACTTGA": {"trancriptome_genome-ratio": "0.838542", "transcriptome_reads": "2,198,977", "related_dataset_id": "EXR-SADAS1EXER1-AN", "fastq_identifier": "sample_Sample_070_PK_Vs_ACTTGA_R1_001_fastq", "biosample_metadata_id": "EXR-SADAS1Ex7004-BS", "exRNA_source": "extracellular vesicle", "cell_culture_source": "Not Applicable", "species": "Human", "anatomical_location": "Entire body system", "RNA_isolation_kit": "MiRVana Paris (Ambion)", "profiling_assay": "small RNA-Seq", "meets_ERCC_QC": "YES", "reference_genome_reads": "2,622,380", "condition": "Healthy Control", "biofluid_name": "Plasma"}}, {"077_BL_Vs_TGACCA": {"trancriptome_genome-ratio": "0.566107", "transcriptome_reads": "1,000,344", "related_dataset_id": "EXR-SADAS1EXER1-AN", "fastq_identifier": "sample_Sample_077_BL_Vs_TGACCA_combined_2_R1_001_fastq", "biosample_metadata_id": "EXR-SADAS1Ex7701-BS", "exRNA_source": "extracellular vesicle", "cell_culture_source": "Not Applicable", "species": "Human", "anatomical_location": "Entire body system", "RNA_isolation_kit": "MiRVana Paris (Ambion)", "profiling_assay": "small RNA-Seq", "meets_ERCC_QC": "YES", "reference_genome_reads": "1,767,058", "condition": "Healthy Control", "biofluid_name": "Plasma"}}, {"077_Ex_BL_AGTTCC": {"trancriptome_genome-ratio": "0.970869", "transcriptome_reads": "2,509,513", "related_dataset_id": "EXR-SADAS1EXER1-AN", "fastq_identifier": "sample_Sample_077_Ex_BL_AGTTCC_R1_001_fastq", "biosample_metadata_id": "EXR-SADAS1Ex7702-BS", "exRNA_source": "total cell-free biofluid RNA", "cell_culture_source": "Not Applicable", "species": "Human", "anatomical_location": "Entire body system", "RNA_isolation_kit": "MiRVana Paris (Ambion)", "profiling_assay": "small RNA-Seq", "meets_ERCC_QC": "YES", "reference_genome_reads": "2,584,812", "condition": "Healthy Control", "biofluid_name": "Plasma"}}, {"077_Ex_PK_GTGAAA": {"trancriptome_genome-ratio": "0.949908", "transcriptome_reads": "4,606,619", "related_dataset_id": "EXR-SADAS1EXER1-AN", "fastq_identifier": "sample_Sample_077_Ex_PK_GTGAAA_R1_001_fastq", "biosample_metadata_id": "EXR-SADAS1Ex7703-BS", "exRNA_source": "total cell-free biofluid RNA", "cell_culture_source": "Not Applicable", "species": "Human", "anatomical_location": "Entire body system", "RNA_isolation_kit": "MiRVana Paris (Ambion)", "profiling_assay": "small RNA-Seq", "meets_ERCC_QC": "YES", "reference_genome_reads": "4,849,542", "condition": "Healthy Control", "biofluid_name": "Plasma"}}, {"077_PK_Vs_GATCAG": {"trancriptome_genome-ratio": "0.378053", "transcriptome_reads": "333,378", "related_dataset_id": "EXR-SADAS1EXER1-AN", "fastq_identifier": "sample_Sample_077_PK_Vs_GATCAG_combined_2_R1_001_fastq", "biosample_metadata_id": "EXR-SADAS1Ex7704-BS", "exRNA_source": "extracellular vesicle", "cell_culture_source": "Not Applicable", "species": "Human", "anatomical_location": "Entire body system", "RNA_isolation_kit": "MiRVana Paris (Ambion)", "profiling_assay": "small RNA-Seq", "meets_ERCC_QC": "NO", "reference_genome_reads": "881,828", "condition": "Healthy Control", "biofluid_name": "Plasma"}}, {"078_BL_Vs_ACAGTG": {"trancriptome_genome-ratio": "0.91251", "transcriptome_reads": "3,901,117", "related_dataset_id": "EXR-SADAS1EXER1-AN", "fastq_identifier": "sample_Sample_078_BL_Vs_ACAGTG_R1_001_fastq", "biosample_metadata_id": "EXR-SADAS1Ex7801-BS", "exRNA_source": "extracellular vesicle", "cell_culture_source": "Not Applicable", "species": "Human", "anatomical_location": "Entire body system", "RNA_isolation_kit": "MiRVana Paris (Ambion)", "profiling_assay": "small RNA-Seq", "meets_ERCC_QC": "YES", "reference_genome_reads": "4,275,152", "condition": "Healthy Control", "biofluid_name": "Plasma"}}, {"078_Ex_BL_ATGTCA": {"trancriptome_genome-ratio": "0.988564", "transcriptome_reads": "8,027,788", "related_dataset_id": "EXR-SADAS1EXER1-AN", "fastq_identifier": "sample_Sample_078_Ex_BL_ATGTCA_R1_001_fastq", "biosample_metadata_id": "EXR-SADAS1Ex7802-BS", "exRNA_source": "total cell-free biofluid RNA", "cell_culture_source": "Not Applicable", "species": "Human", "anatomical_location": "Entire body system", "RNA_isolation_kit": "MiRVana Paris (Ambion)", "profiling_assay": "small RNA-Seq", "meets_ERCC_QC": "YES", "reference_genome_reads": "8,120,656", "condition": "Healthy Control", "biofluid_name": "Plasma"}}, {"078_Ex_PK_GTGGCC": {"trancriptome_genome-ratio": "0.979813", "transcriptome_reads": "2,127,188", "related_dataset_id": "EXR-SADAS1EXER1-AN", "fastq_identifier": "sample_Sample_078_Ex_PK_GTGGCC_R1_001_fastq", "biosample_metadata_id": "EXR-SADAS1Ex7803-BS", "exRNA_source": "total cell-free biofluid RNA", "cell_culture_source": "Not Applicable", "species": "Human", "anatomical_location": "Entire body system", "RNA_isolation_kit": "MiRVana Paris (Ambion)", "profiling_assay": "small RNA-Seq", "meets_ERCC_QC": "YES", "reference_genome_reads": "2,171,015", "condition": "Healthy Control", "biofluid_name": "Plasma"}}, {"078_PK_Vs_TAGCTT": {"trancriptome_genome-ratio": "0.968405", "transcriptome_reads": "5,086,697", "related_dataset_id": "EXR-SADAS1EXER1-AN", "fastq_identifier": "sample_Sample_078_PK_Vs_TAGCTT_R1_001_fastq", "biosample_metadata_id": "EXR-SADAS1Ex7804-BS", "exRNA_source": "extracellular vesicle", "cell_culture_source": "Not Applicable", "species": "Human", "anatomical_location": "Entire body system", "RNA_isolation_kit": "MiRVana Paris (Ambion)", "profiling_assay": "small RNA-Seq", "meets_ERCC_QC": "YES", "reference_genome_reads": "5,252,655", "condition": "Healthy Control", "biofluid_name": "Plasma"}}], "ownerprofile_id": "unknown", "platform": 21, "summary_wrapped": "Exercise improves cardiometabolic and vascular function, though mechanisms remain unclear. Our objective was to demonstrate the diversity...", "pubmed_id": "28916639", "owner_profile": "/profile/10501/ercc", "factor_count": 15, "sample_count": 62, "tags": [], "sample_geneid": "100423015", "lastmodified": "Jul.30, 2018", "is_default": false, "geo_gds_id": "unknown", "slug": "small-rna-seq-during-acute-maximal-exercise-reveal", "geo_id_plat": "unknown", "name": "Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health", "created": "Jul.30, 2018", "summary": "Exercise improves cardiometabolic and vascular function, though mechanisms remain unclear. Our objective was to demonstrate the diversity of circulating extracellular RNA (ex-RNA) release during acute exercise in humans and its relevance to exercise-mediated benefits on vascular inflammation. We performed plasma small RNA sequencing (RNA-seq) in 26 individuals undergoing symptom-limited maximal treadmill exercise, with replication of our top candidate miRNA in a separate cohort of 59 individuals undergoing bicycle ergometry. We found changes in miRNAs and other ex-RNAs with exercise (e.g., y-RNAs, t-RNAs) implicated in cardiovascular disease. In two independent cohorts of acute maximal exercise, we identified miR-181b-5p as a key ex-RNA increased in plasma after exercise, with validation in a separate cohort. In a mouse model of acute exercise, we found significant increases in miR-181b-5p expression in skeletal muscle after acute exercise in young (but not older) mice. Previous work revealed a strong role for miR-181b-5p in vascular inflammation in obesity, insulin resistance, sepsis, and cardiovascular disease. Circulating ex-RNAs altered in plasma after acute exercise target pathways involved in inflammation, including miR-181b-5p. Further investigation into the role of known (e.g., miRNA) and novel (e.g., y-RNAs) is warranted to uncover new mechanisms of vascular inflammation on exercise-mediated benefits on health.", "geo_gse_id": "BDS_00038", "species": "human"}