Dataset: Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health

Exercise improves cardiometabolic and vascular function, though mechanisms remain unclear. Our objective was to demonstrate the diversity...

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Exercise improves cardiometabolic and vascular function, though mechanisms remain unclear. Our objective was to demonstrate the diversity of circulating extracellular RNA (ex-RNA) release during acute exercise in humans and its relevance to exercise-mediated benefits on vascular inflammation. We performed plasma small RNA sequencing (RNA-seq) in 26 individuals undergoing symptom-limited maximal treadmill exercise, with replication of our top candidate miRNA in a separate cohort of 59 individuals undergoing bicycle ergometry. We found changes in miRNAs and other ex-RNAs with exercise (e.g., y-RNAs, t-RNAs) implicated in cardiovascular disease. In two independent cohorts of acute maximal exercise, we identified miR-181b-5p as a key ex-RNA increased in plasma after exercise, with validation in a separate cohort. In a mouse model of acute exercise, we found significant increases in miR-181b-5p expression in skeletal muscle after acute exercise in young (but not older) mice. Previous work revealed a strong role for miR-181b-5p in vascular inflammation in obesity, insulin resistance, sepsis, and cardiovascular disease. Circulating ex-RNAs altered in plasma after acute exercise target pathways involved in inflammation, including miR-181b-5p. Further investigation into the role of known (e.g., miRNA) and novel (e.g., y-RNAs) is warranted to uncover new mechanisms of vascular inflammation on exercise-mediated benefits on health.

Species:: human
Samples:: 62
PubMed:: 28916639
Updated:: Jul.30, 2018
Registered:: Jul.30, 2018

Factors:

Sample	trancriptome_genome-ratio	transcriptome_reads	related_dataset_id	fastq_identifier	biosample_metadata_id	exRNA_source	cell_culture_source	reference_genome_reads	condition	RNA_isolation_kit	profiling_assay	meets_ERCC_QC	species	anatomical_location	biofluid_name
003_EX_BL_CAGATC	0.973572	6,198,668	EXR-SADAS1EXER1-AN	sample_Sample_003_EX_BL_CAGATC_R1_001_fastq	EXR-SADAS1Ex0301-BS	total cell-free biofluid RNA	Not Applicable	6,366,933	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
003_EX_PK_CAACTA	0.946357	6,385,726	EXR-SADAS1EXER1-AN	sample_Sample_003_EX_PK_CAACTA_R1_001_fastq	EXR-SADAS1Ex0302-BS	total cell-free biofluid RNA	Not Applicable	6,747,691	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
004_EX_BL_TAGCTT	0.991163	7,005,992	EXR-SADAS1EXER1-AN	sample_Sample_004_EX_BL_TAGCTT_R1_001_fastq	EXR-SADAS1Ex0401-BS	total cell-free biofluid RNA	Not Applicable	7,068,457	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
004_EX_PK_CGGAAT	0.925257	4,763,934	EXR-SADAS1EXER1-AN	sample_Sample_004_EX_PK_CGGAAT_R1_001_fastq	EXR-SADAS1Ex0402-BS	total cell-free biofluid RNA	Not Applicable	5,148,767	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
006_EX_BL_ACTTGA	0.982302	6,565,482	EXR-SADAS1EXER1-AN	sample_Sample_006_EX_BL_ACTTGA_R1_001_fastq	EXR-SADAS1Ex0601-BS	total cell-free biofluid RNA	Not Applicable	6,683,771	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
006_EX_PK_CAGGCG	0.961273	4,691,395	EXR-SADAS1EXER1-AN	sample_Sample_006_EX_PK_CAGGCG_R1_001_fastq	EXR-SADAS1Ex0602-BS	total cell-free biofluid RNA	Not Applicable	4,880,400	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
007_EX_BL_ATCACG	0.966537	5,040,038	EXR-SADAS1EXER1-AN	sample_Sample_007_EX_BL_ATCACG_R1_001_fastq	EXR-SADAS1Ex0701-BS	total cell-free biofluid RNA	Not Applicable	5,214,531	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
007_EX_PK_GGCTAC	0.954422	4,000,090	EXR-SADAS1EXER1-AN	sample_Sample_007_EX_PK_GGCTAC_R1_001_fastq	EXR-SADAS1Ex0702-BS	total cell-free biofluid RNA	Not Applicable	4,191,113	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
010_EX_BL_CTTGTA	0.975999	6,184,812	EXR-SADAS1EXER1-AN	sample_Sample_010_EX_BL_CTTGTA_R1_001_fastq	EXR-SADAS1Ex1001-BS	total cell-free biofluid RNA	Not Applicable	6,336,905	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
010_EX_PK_CAAAAG	0.92714	4,154,267	EXR-SADAS1EXER1-AN	sample_Sample_010_EX_PK_CAAAAG_R1_001_fastq	EXR-SADAS1Ex1002-BS	total cell-free biofluid RNA	Not Applicable	4,480,735	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
012_EX_BL_ACTGAT	0.673709	393,397	EXR-SADAS1EXER1-AN	sample_Sample_012_EX_BL_ACTGAT_combined_2_R1_001_fastq	EXR-SADAS1Ex1201-BS	total cell-free biofluid RNA	Not Applicable	583,927	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
012_EX_PK_CACTCA	0.959807	4,298,537	EXR-SADAS1EXER1-AN	sample_Sample_012_EX_PK_CACTCA_R1_001_fastq	EXR-SADAS1Ex1202-BS	total cell-free biofluid RNA	Not Applicable	4,478,541	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
013_EX_BL_GAGTGG	0.903039	971,498	EXR-SADAS1EXER1-AN	sample_Sample_013_EX_BL_GAGTGG_R1_001_fastq	EXR-SADAS1Ex1301-BS	total cell-free biofluid RNA	Not Applicable	1,075,810	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
013_EX_PK_ATTCCT	0.925232	2,729,074	EXR-SADAS1EXER1-AN	sample_Sample_013_EX_PK_ATTCCT_R1_001_fastq	EXR-SADAS1Ex1302-BS	total cell-free biofluid RNA	Not Applicable	2,949,612	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
014_EX_BL_ACAGTG	0.970692	4,240,675	EXR-SADAS1EXER1-AN	sample_Sample_014_EX_BL_ACAGTG_R1_001_fastq	EXR-SADAS1Ex1401-BS	total cell-free biofluid RNA	Not Applicable	4,368,712	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
014_EX_PK_GTAGAG	0.958312	5,727,496	EXR-SADAS1EXER1-AN	sample_Sample_014_EX_PK_GTAGAG_R1_001_fastq	EXR-SADAS1Ex1402-BS	total cell-free biofluid RNA	Not Applicable	5,976,651	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
018_EX_BL_GTGAAA	0.288149	138,797	EXR-SADAS1EXER1-AN	sample_Sample_018_EX_BL_GTGAAA_combined_2_R1_001_fastq	EXR-SADAS1Ex1801-BS	total cell-free biofluid RNA	Not Applicable	481,685	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	NO	Human	Entire body system	Plasma
018_EX_PK_TTAGGC	0.976454	4,489,788	EXR-SADAS1EXER1-AN	sample_Sample_018_EX_PK_TTAGGC_R1_001_fastq	EXR-SADAS1Ex1802-BS	total cell-free biofluid RNA	Not Applicable	4,598,055	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
019_EX_BL_GATCAG	0.970272	4,126,161	EXR-SADAS1EXER1-AN	sample_Sample_019_EX_BL_GATCAG_R1_001_fastq	EXR-SADAS1Ex1901-BS	total cell-free biofluid RNA	Not Applicable	4,252,581	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
019_EX_PK_ATGAGC	0.948937	3,921,983	EXR-SADAS1EXER1-AN	sample_Sample_019_EX_PK_ATGAGC_R1_001_fastq	EXR-SADAS1Ex1902-BS	total cell-free biofluid RNA	Not Applicable	4,133,029	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
023_EX_BL_GTTTCG	0.992686	4,969,606	EXR-SADAS1EXER1-AN	sample_Sample_023_EX_BL_GTTTCG_R1_001_fastq	EXR-SADAS1Ex2301-BS	total cell-free biofluid RNA	Not Applicable	5,006,223	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
023_EX_PK_TGACCA	0.977603	5,213,865	EXR-SADAS1EXER1-AN	sample_Sample_023_EX_PK_TGACCA_R1_001_fastq	EXR-SADAS1Ex2302-BS	total cell-free biofluid RNA	Not Applicable	5,333,315	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
024_EX_BL_AGTCAA	0.851699	861,043	EXR-SADAS1EXER1-AN	sample_Sample_024_EX_BL_AGTCAA_combined_2_R1_001_fastq	EXR-SADAS1Ex2401-BS	total cell-free biofluid RNA	Not Applicable	1,010,971	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
024_EX_PK_CTATAC	0.910007	3,333,574	EXR-SADAS1EXER1-AN	sample_Sample_024_EX_PK_CTATAC_R1_001_fastq	EXR-SADAS1Ex2402-BS	total cell-free biofluid RNA	Not Applicable	3,663,238	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
025_EX_BL_GGTAGC	0.886569	1,122,167	EXR-SADAS1EXER1-AN	sample_Sample_025_EX_BL_GGTAGC_R1_001_fastq	EXR-SADAS1Ex2501-BS	total cell-free biofluid RNA	Not Applicable	1,265,742	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
025_EX_PK_CCGTCC	0.866196	3,551,632	EXR-SADAS1EXER1-AN	sample_Sample_025_EX_PK_CCGTCC_R1_001_fastq	EXR-SADAS1Ex2502-BS	total cell-free biofluid RNA	Not Applicable	4,100,266	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
026_EX_BL_GCCAAT	0.981879	6,616,604	EXR-SADAS1EXER1-AN	sample_Sample_026_EX_BL_GCCAAT_R1_001_fastq	EXR-SADAS1Ex2601-BS	total cell-free biofluid RNA	Not Applicable	6,738,716	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
026_EX_PK_CATGGC	0.622645	2,513,733	EXR-SADAS1EXER1-AN	sample_Sample_026_EX_PK_CATGGC_combined_2_R1_001_fastq	EXR-SADAS1Ex2602-BS	total cell-free biofluid RNA	Not Applicable	4,037,185	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
027_EX_BL_GTGGCC	0.964937	5,421,905	EXR-SADAS1EXER1-AN	sample_Sample_027_EX_BL_GTGGCC_R1_001_fastq	EXR-SADAS1Ex2701-BS	total cell-free biofluid RNA	Not Applicable	5,618,924	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
027_EX_PK_CACGAT	0.927445	7,468,854	EXR-SADAS1EXER1-AN	sample_Sample_027_EX_PK_CACGAT_R1_001_fastq	EXR-SADAS1Ex2702-BS	total cell-free biofluid RNA	Not Applicable	8,053,154	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
028_EX_BL_AGTTCC	0.973764	6,229,620	EXR-SADAS1EXER1-AN	sample_Sample_028_EX_BL_AGTTCC_R1_001_fastq	EXR-SADAS1Ex2801-BS	total cell-free biofluid RNA	Not Applicable	6,397,463	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
028_EX_PK_CTCAGA	0.976387	8,112,878	EXR-SADAS1EXER1-AN	sample_Sample_028_EX_PK_CTCAGA_R1_001_fastq	EXR-SADAS1Ex2802-BS	total cell-free biofluid RNA	Not Applicable	8,309,078	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
029_EX_BL_CGATGT	0.946025	2,650,656	EXR-SADAS1EXER1-AN	sample_Sample_029_EX_BL_CGATGT_R1_001_fastq	EXR-SADAS1Ex2901-BS	total cell-free biofluid RNA	Not Applicable	2,801,887	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
029_EX_PK_CTAGCT	0.932021	4,921,196	EXR-SADAS1EXER1-AN	sample_Sample_029_EX_PK_CTAGCT_R1_001_fastq	EXR-SADAS1Ex2902-BS	total cell-free biofluid RNA	Not Applicable	5,280,133	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
030_EX_BL_CGTACG	0.617294	371,861	EXR-SADAS1EXER1-AN	sample_Sample_030_EX_BL_CGTACG_combined_2_R1_001_fastq	EXR-SADAS1Ex3001-BS	total cell-free biofluid RNA	Not Applicable	602,405	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
030_EX_PK_GACGAC	0.864368	3,281,101	EXR-SADAS1EXER1-AN	sample_Sample_030_EX_PK_GACGAC_R1_001_fastq	EXR-SADAS1Ex3002-BS	total cell-free biofluid RNA	Not Applicable	3,795,956	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
031_EX_BL_GTCCGC	0.955371	4,536,552	EXR-SADAS1EXER1-AN	sample_Sample_031_EX_BL_GTCCGC_R1_001_fastq	EXR-SADAS1Ex3101-BS	total cell-free biofluid RNA	Not Applicable	4,748,474	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
031_EX_PK_CCAACA	0.956799	5,450,772	EXR-SADAS1EXER1-AN	sample_Sample_031_EX_PK_CCAACA_R1_001_fastq	EXR-SADAS1Ex3102-BS	total cell-free biofluid RNA	Not Applicable	5,696,881	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
032_EX_BL_ATGTCA	0.987461	8,627,840	EXR-SADAS1EXER1-AN	sample_Sample_032_EX_BL_ATGTCA_R1_001_fastq	EXR-SADAS1Ex3201-BS	total cell-free biofluid RNA	Not Applicable	8,737,396	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
032_EX_PK_CATTTT	0.963935	5,865,851	EXR-SADAS1EXER1-AN	sample_Sample_032_EX_PK_CATTTT_R1_001_fastq	EXR-SADAS1Ex3202-BS	total cell-free biofluid RNA	Not Applicable	6,085,317	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
044_BL_Vs_ATCACG	0.915619	3,558,844	EXR-SADAS1EXER1-AN	sample_Sample_044_BL_Vs_ATCACG_R1_001_fastq	EXR-SADAS1Ex4401-BS	extracellular vesicle	Not Applicable	3,886,818	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
044_Ex_BL_GGCTAC	0.988234	5,783,466	EXR-SADAS1EXER1-AN	sample_Sample_044_Ex_BL_GGCTAC_R1_001_fastq	EXR-SADAS1Ex4402-BS	total cell-free biofluid RNA	Not Applicable	5,852,322	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
044_Ex_PK_CCGTCC	0.977318	3,341,569	EXR-SADAS1EXER1-AN	sample_Sample_044_Ex_PK_CCGTCC_R1_001_fastq	EXR-SADAS1Ex4403-BS	total cell-free biofluid RNA	Not Applicable	3,419,123	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
044_PK_Vs_GCCAAT	0.50682	849,163	EXR-SADAS1EXER1-AN	sample_Sample_044_PK_Vs_GCCAAT_combined_2_R1_001_fastq	EXR-SADAS1Ex4404-BS	extracellular vesicle	Not Applicable	1,675,473	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
059_EX_BL_CACCGG	0.996979	4,729,657	EXR-SADAS1EXER1-AN	sample_Sample_059_EX_BL_CACCGG_R1_001_fastq	EXR-SADAS1Ex5901-BS	total cell-free biofluid RNA	Not Applicable	4,743,989	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
059_EX_PK_TAATCG	0.997398	10,941,804	EXR-SADAS1EXER1-AN	sample_Sample_059_EX_PK_TAATCG_combined_2_R1_001_fastq	EXR-SADAS1Ex5902-BS	total cell-free biofluid RNA	Not Applicable	10,970,346	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
068_BL_Vs_CGATGT	0.475969	770,280	EXR-SADAS1EXER1-AN	sample_Sample_068_BL_Vs_CGATGT_combined_2_R1_001_fastq	EXR-SADAS1Ex6801-BS	extracellular vesicle	Not Applicable	1,618,341	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	NO	Human	Entire body system	Plasma
068_Ex_BL_CTTGTA	0.995714	10,070,795	EXR-SADAS1EXER1-AN	sample_Sample_068_Ex_BL_CTTGTA_R1_001_fastq	EXR-SADAS1Ex6802-BS	total cell-free biofluid RNA	Not Applicable	10,114,141	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
068_Ex_PK_GTAGAG	0.942621	1,590,435	EXR-SADAS1EXER1-AN	sample_Sample_068_Ex_PK_GTAGAG_R1_001_fastq	EXR-SADAS1Ex6803-BS	total cell-free biofluid RNA	Not Applicable	1,687,248	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
068_PK_Vs_CAGATC	0.469104	199,597	EXR-SADAS1EXER1-AN	sample_Sample_068_PK_Vs_CAGATC_R1_001_fastq	EXR-SADAS1Ex6804-BS	extracellular vesicle	Not Applicable	425,486	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	NO	Human	Entire body system	Plasma
070_BL_Vs_TTAGGC	0.844106	2,414,319	EXR-SADAS1EXER1-AN	sample_Sample_070_BL_Vs_TTAGGC_R1_001_fastq	EXR-SADAS1Ex7001-BS	extracellular vesicle	Not Applicable	2,860,210	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
070_Ex_BL_AGTCAA	0.980084	6,399,067	EXR-SADAS1EXER1-AN	sample_Sample_070_Ex_BL_AGTCAA_R1_001_fastq	EXR-SADAS1Ex7002-BS	total cell-free biofluid RNA	Not Applicable	6,529,102	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
070_Ex_PK_GTCCGC	0.973877	1,974,718	EXR-SADAS1EXER1-AN	sample_Sample_070_Ex_PK_GTCCGC_R1_001_fastq	EXR-SADAS1Ex7003-BS	total cell-free biofluid RNA	Not Applicable	2,027,688	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
070_PK_Vs_ACTTGA	0.838542	2,198,977	EXR-SADAS1EXER1-AN	sample_Sample_070_PK_Vs_ACTTGA_R1_001_fastq	EXR-SADAS1Ex7004-BS	extracellular vesicle	Not Applicable	2,622,380	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
077_BL_Vs_TGACCA	0.566107	1,000,344	EXR-SADAS1EXER1-AN	sample_Sample_077_BL_Vs_TGACCA_combined_2_R1_001_fastq	EXR-SADAS1Ex7701-BS	extracellular vesicle	Not Applicable	1,767,058	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
077_Ex_BL_AGTTCC	0.970869	2,509,513	EXR-SADAS1EXER1-AN	sample_Sample_077_Ex_BL_AGTTCC_R1_001_fastq	EXR-SADAS1Ex7702-BS	total cell-free biofluid RNA	Not Applicable	2,584,812	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
077_Ex_PK_GTGAAA	0.949908	4,606,619	EXR-SADAS1EXER1-AN	sample_Sample_077_Ex_PK_GTGAAA_R1_001_fastq	EXR-SADAS1Ex7703-BS	total cell-free biofluid RNA	Not Applicable	4,849,542	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
077_PK_Vs_GATCAG	0.378053	333,378	EXR-SADAS1EXER1-AN	sample_Sample_077_PK_Vs_GATCAG_combined_2_R1_001_fastq	EXR-SADAS1Ex7704-BS	extracellular vesicle	Not Applicable	881,828	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	NO	Human	Entire body system	Plasma
078_BL_Vs_ACAGTG	0.91251	3,901,117	EXR-SADAS1EXER1-AN	sample_Sample_078_BL_Vs_ACAGTG_R1_001_fastq	EXR-SADAS1Ex7801-BS	extracellular vesicle	Not Applicable	4,275,152	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
078_Ex_BL_ATGTCA	0.988564	8,027,788	EXR-SADAS1EXER1-AN	sample_Sample_078_Ex_BL_ATGTCA_R1_001_fastq	EXR-SADAS1Ex7802-BS	total cell-free biofluid RNA	Not Applicable	8,120,656	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
078_Ex_PK_GTGGCC	0.979813	2,127,188	EXR-SADAS1EXER1-AN	sample_Sample_078_Ex_PK_GTGGCC_R1_001_fastq	EXR-SADAS1Ex7803-BS	total cell-free biofluid RNA	Not Applicable	2,171,015	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma
078_PK_Vs_TAGCTT	0.968405	5,086,697	EXR-SADAS1EXER1-AN	sample_Sample_078_PK_Vs_TAGCTT_R1_001_fastq	EXR-SADAS1Ex7804-BS	extracellular vesicle	Not Applicable	5,252,655	Healthy Control	MiRVana Paris (Ambion)	small RNA-Seq	YES	Human	Entire body system	Plasma