Dataset: Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health

Exercise improves cardiometabolic and vascular function, though mechanisms remain unclear. Our objective was to demonstrate the diversity...

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Exercise improves cardiometabolic and vascular function, though mechanisms remain unclear. Our objective was to demonstrate the diversity of circulating extracellular RNA (ex-RNA) release during acute exercise in humans and its relevance to exercise-mediated benefits on vascular inflammation. We performed plasma small RNA sequencing (RNA-seq) in 26 individuals undergoing symptom-limited maximal treadmill exercise, with replication of our top candidate miRNA in a separate cohort of 59 individuals undergoing bicycle ergometry. We found changes in miRNAs and other ex-RNAs with exercise (e.g., y-RNAs, t-RNAs) implicated in cardiovascular disease. In two independent cohorts of acute maximal exercise, we identified miR-181b-5p as a key ex-RNA increased in plasma after exercise, with validation in a separate cohort. In a mouse model of acute exercise, we found significant increases in miR-181b-5p expression in skeletal muscle after acute exercise in young (but not older) mice. Previous work revealed a strong role for miR-181b-5p in vascular inflammation in obesity, insulin resistance, sepsis, and cardiovascular disease. Circulating ex-RNAs altered in plasma after acute exercise target pathways involved in inflammation, including miR-181b-5p. Further investigation into the role of known (e.g., miRNA) and novel (e.g., y-RNAs) is warranted to uncover new mechanisms of vascular inflammation on exercise-mediated benefits on health.

Species:: human
Samples:: 62
PubMed:: 28916639
Updated:: Jul.30, 2018
Registered:: Jul.30, 2018

Factors:

Sample	trancriptome_genome-ratio	cell_culture_source	related_dataset_id	fastq_identifier	biosample_metadata_id	exRNA_source	transcriptome_reads	species	anatomical_location	RNA_isolation_kit	profiling_assay	meets_ERCC_QC	reference_genome_reads	condition	biofluid_name
003_EX_BL_CAGATC	0.973572	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_003_EX_BL_CAGATC_R1_001_fastq	EXR-SADAS1Ex0301-BS	total cell-free biofluid RNA	6,198,668	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	6,366,933	Healthy Control	Plasma
003_EX_PK_CAACTA	0.946357	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_003_EX_PK_CAACTA_R1_001_fastq	EXR-SADAS1Ex0302-BS	total cell-free biofluid RNA	6,385,726	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	6,747,691	Healthy Control	Plasma
004_EX_BL_TAGCTT	0.991163	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_004_EX_BL_TAGCTT_R1_001_fastq	EXR-SADAS1Ex0401-BS	total cell-free biofluid RNA	7,005,992	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	7,068,457	Healthy Control	Plasma
004_EX_PK_CGGAAT	0.925257	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_004_EX_PK_CGGAAT_R1_001_fastq	EXR-SADAS1Ex0402-BS	total cell-free biofluid RNA	4,763,934	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	5,148,767	Healthy Control	Plasma
006_EX_BL_ACTTGA	0.982302	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_006_EX_BL_ACTTGA_R1_001_fastq	EXR-SADAS1Ex0601-BS	total cell-free biofluid RNA	6,565,482	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	6,683,771	Healthy Control	Plasma
006_EX_PK_CAGGCG	0.961273	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_006_EX_PK_CAGGCG_R1_001_fastq	EXR-SADAS1Ex0602-BS	total cell-free biofluid RNA	4,691,395	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	4,880,400	Healthy Control	Plasma
007_EX_BL_ATCACG	0.966537	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_007_EX_BL_ATCACG_R1_001_fastq	EXR-SADAS1Ex0701-BS	total cell-free biofluid RNA	5,040,038	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	5,214,531	Healthy Control	Plasma
007_EX_PK_GGCTAC	0.954422	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_007_EX_PK_GGCTAC_R1_001_fastq	EXR-SADAS1Ex0702-BS	total cell-free biofluid RNA	4,000,090	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	4,191,113	Healthy Control	Plasma
010_EX_BL_CTTGTA	0.975999	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_010_EX_BL_CTTGTA_R1_001_fastq	EXR-SADAS1Ex1001-BS	total cell-free biofluid RNA	6,184,812	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	6,336,905	Healthy Control	Plasma
010_EX_PK_CAAAAG	0.92714	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_010_EX_PK_CAAAAG_R1_001_fastq	EXR-SADAS1Ex1002-BS	total cell-free biofluid RNA	4,154,267	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	4,480,735	Healthy Control	Plasma
012_EX_BL_ACTGAT	0.673709	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_012_EX_BL_ACTGAT_combined_2_R1_001_fastq	EXR-SADAS1Ex1201-BS	total cell-free biofluid RNA	393,397	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	583,927	Healthy Control	Plasma
012_EX_PK_CACTCA	0.959807	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_012_EX_PK_CACTCA_R1_001_fastq	EXR-SADAS1Ex1202-BS	total cell-free biofluid RNA	4,298,537	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	4,478,541	Healthy Control	Plasma
013_EX_BL_GAGTGG	0.903039	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_013_EX_BL_GAGTGG_R1_001_fastq	EXR-SADAS1Ex1301-BS	total cell-free biofluid RNA	971,498	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	1,075,810	Healthy Control	Plasma
013_EX_PK_ATTCCT	0.925232	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_013_EX_PK_ATTCCT_R1_001_fastq	EXR-SADAS1Ex1302-BS	total cell-free biofluid RNA	2,729,074	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	2,949,612	Healthy Control	Plasma
014_EX_BL_ACAGTG	0.970692	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_014_EX_BL_ACAGTG_R1_001_fastq	EXR-SADAS1Ex1401-BS	total cell-free biofluid RNA	4,240,675	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	4,368,712	Healthy Control	Plasma
014_EX_PK_GTAGAG	0.958312	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_014_EX_PK_GTAGAG_R1_001_fastq	EXR-SADAS1Ex1402-BS	total cell-free biofluid RNA	5,727,496	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	5,976,651	Healthy Control	Plasma
018_EX_BL_GTGAAA	0.288149	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_018_EX_BL_GTGAAA_combined_2_R1_001_fastq	EXR-SADAS1Ex1801-BS	total cell-free biofluid RNA	138,797	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	NO	481,685	Healthy Control	Plasma
018_EX_PK_TTAGGC	0.976454	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_018_EX_PK_TTAGGC_R1_001_fastq	EXR-SADAS1Ex1802-BS	total cell-free biofluid RNA	4,489,788	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	4,598,055	Healthy Control	Plasma
019_EX_BL_GATCAG	0.970272	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_019_EX_BL_GATCAG_R1_001_fastq	EXR-SADAS1Ex1901-BS	total cell-free biofluid RNA	4,126,161	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	4,252,581	Healthy Control	Plasma
019_EX_PK_ATGAGC	0.948937	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_019_EX_PK_ATGAGC_R1_001_fastq	EXR-SADAS1Ex1902-BS	total cell-free biofluid RNA	3,921,983	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	4,133,029	Healthy Control	Plasma
023_EX_BL_GTTTCG	0.992686	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_023_EX_BL_GTTTCG_R1_001_fastq	EXR-SADAS1Ex2301-BS	total cell-free biofluid RNA	4,969,606	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	5,006,223	Healthy Control	Plasma
023_EX_PK_TGACCA	0.977603	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_023_EX_PK_TGACCA_R1_001_fastq	EXR-SADAS1Ex2302-BS	total cell-free biofluid RNA	5,213,865	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	5,333,315	Healthy Control	Plasma
024_EX_BL_AGTCAA	0.851699	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_024_EX_BL_AGTCAA_combined_2_R1_001_fastq	EXR-SADAS1Ex2401-BS	total cell-free biofluid RNA	861,043	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	1,010,971	Healthy Control	Plasma
024_EX_PK_CTATAC	0.910007	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_024_EX_PK_CTATAC_R1_001_fastq	EXR-SADAS1Ex2402-BS	total cell-free biofluid RNA	3,333,574	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	3,663,238	Healthy Control	Plasma
025_EX_BL_GGTAGC	0.886569	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_025_EX_BL_GGTAGC_R1_001_fastq	EXR-SADAS1Ex2501-BS	total cell-free biofluid RNA	1,122,167	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	1,265,742	Healthy Control	Plasma
025_EX_PK_CCGTCC	0.866196	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_025_EX_PK_CCGTCC_R1_001_fastq	EXR-SADAS1Ex2502-BS	total cell-free biofluid RNA	3,551,632	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	4,100,266	Healthy Control	Plasma
026_EX_BL_GCCAAT	0.981879	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_026_EX_BL_GCCAAT_R1_001_fastq	EXR-SADAS1Ex2601-BS	total cell-free biofluid RNA	6,616,604	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	6,738,716	Healthy Control	Plasma
026_EX_PK_CATGGC	0.622645	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_026_EX_PK_CATGGC_combined_2_R1_001_fastq	EXR-SADAS1Ex2602-BS	total cell-free biofluid RNA	2,513,733	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	4,037,185	Healthy Control	Plasma
027_EX_BL_GTGGCC	0.964937	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_027_EX_BL_GTGGCC_R1_001_fastq	EXR-SADAS1Ex2701-BS	total cell-free biofluid RNA	5,421,905	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	5,618,924	Healthy Control	Plasma
027_EX_PK_CACGAT	0.927445	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_027_EX_PK_CACGAT_R1_001_fastq	EXR-SADAS1Ex2702-BS	total cell-free biofluid RNA	7,468,854	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	8,053,154	Healthy Control	Plasma
028_EX_BL_AGTTCC	0.973764	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_028_EX_BL_AGTTCC_R1_001_fastq	EXR-SADAS1Ex2801-BS	total cell-free biofluid RNA	6,229,620	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	6,397,463	Healthy Control	Plasma
028_EX_PK_CTCAGA	0.976387	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_028_EX_PK_CTCAGA_R1_001_fastq	EXR-SADAS1Ex2802-BS	total cell-free biofluid RNA	8,112,878	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	8,309,078	Healthy Control	Plasma
029_EX_BL_CGATGT	0.946025	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_029_EX_BL_CGATGT_R1_001_fastq	EXR-SADAS1Ex2901-BS	total cell-free biofluid RNA	2,650,656	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	2,801,887	Healthy Control	Plasma
029_EX_PK_CTAGCT	0.932021	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_029_EX_PK_CTAGCT_R1_001_fastq	EXR-SADAS1Ex2902-BS	total cell-free biofluid RNA	4,921,196	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	5,280,133	Healthy Control	Plasma
030_EX_BL_CGTACG	0.617294	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_030_EX_BL_CGTACG_combined_2_R1_001_fastq	EXR-SADAS1Ex3001-BS	total cell-free biofluid RNA	371,861	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	602,405	Healthy Control	Plasma
030_EX_PK_GACGAC	0.864368	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_030_EX_PK_GACGAC_R1_001_fastq	EXR-SADAS1Ex3002-BS	total cell-free biofluid RNA	3,281,101	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	3,795,956	Healthy Control	Plasma
031_EX_BL_GTCCGC	0.955371	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_031_EX_BL_GTCCGC_R1_001_fastq	EXR-SADAS1Ex3101-BS	total cell-free biofluid RNA	4,536,552	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	4,748,474	Healthy Control	Plasma
031_EX_PK_CCAACA	0.956799	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_031_EX_PK_CCAACA_R1_001_fastq	EXR-SADAS1Ex3102-BS	total cell-free biofluid RNA	5,450,772	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	5,696,881	Healthy Control	Plasma
032_EX_BL_ATGTCA	0.987461	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_032_EX_BL_ATGTCA_R1_001_fastq	EXR-SADAS1Ex3201-BS	total cell-free biofluid RNA	8,627,840	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	8,737,396	Healthy Control	Plasma
032_EX_PK_CATTTT	0.963935	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_032_EX_PK_CATTTT_R1_001_fastq	EXR-SADAS1Ex3202-BS	total cell-free biofluid RNA	5,865,851	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	6,085,317	Healthy Control	Plasma
044_BL_Vs_ATCACG	0.915619	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_044_BL_Vs_ATCACG_R1_001_fastq	EXR-SADAS1Ex4401-BS	extracellular vesicle	3,558,844	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	3,886,818	Healthy Control	Plasma
044_Ex_BL_GGCTAC	0.988234	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_044_Ex_BL_GGCTAC_R1_001_fastq	EXR-SADAS1Ex4402-BS	total cell-free biofluid RNA	5,783,466	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	5,852,322	Healthy Control	Plasma
044_Ex_PK_CCGTCC	0.977318	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_044_Ex_PK_CCGTCC_R1_001_fastq	EXR-SADAS1Ex4403-BS	total cell-free biofluid RNA	3,341,569	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	3,419,123	Healthy Control	Plasma
044_PK_Vs_GCCAAT	0.50682	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_044_PK_Vs_GCCAAT_combined_2_R1_001_fastq	EXR-SADAS1Ex4404-BS	extracellular vesicle	849,163	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	1,675,473	Healthy Control	Plasma
059_EX_BL_CACCGG	0.996979	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_059_EX_BL_CACCGG_R1_001_fastq	EXR-SADAS1Ex5901-BS	total cell-free biofluid RNA	4,729,657	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	4,743,989	Healthy Control	Plasma
059_EX_PK_TAATCG	0.997398	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_059_EX_PK_TAATCG_combined_2_R1_001_fastq	EXR-SADAS1Ex5902-BS	total cell-free biofluid RNA	10,941,804	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	10,970,346	Healthy Control	Plasma
068_BL_Vs_CGATGT	0.475969	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_068_BL_Vs_CGATGT_combined_2_R1_001_fastq	EXR-SADAS1Ex6801-BS	extracellular vesicle	770,280	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	NO	1,618,341	Healthy Control	Plasma
068_Ex_BL_CTTGTA	0.995714	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_068_Ex_BL_CTTGTA_R1_001_fastq	EXR-SADAS1Ex6802-BS	total cell-free biofluid RNA	10,070,795	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	10,114,141	Healthy Control	Plasma
068_Ex_PK_GTAGAG	0.942621	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_068_Ex_PK_GTAGAG_R1_001_fastq	EXR-SADAS1Ex6803-BS	total cell-free biofluid RNA	1,590,435	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	1,687,248	Healthy Control	Plasma
068_PK_Vs_CAGATC	0.469104	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_068_PK_Vs_CAGATC_R1_001_fastq	EXR-SADAS1Ex6804-BS	extracellular vesicle	199,597	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	NO	425,486	Healthy Control	Plasma
070_BL_Vs_TTAGGC	0.844106	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_070_BL_Vs_TTAGGC_R1_001_fastq	EXR-SADAS1Ex7001-BS	extracellular vesicle	2,414,319	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	2,860,210	Healthy Control	Plasma
070_Ex_BL_AGTCAA	0.980084	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_070_Ex_BL_AGTCAA_R1_001_fastq	EXR-SADAS1Ex7002-BS	total cell-free biofluid RNA	6,399,067	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	6,529,102	Healthy Control	Plasma
070_Ex_PK_GTCCGC	0.973877	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_070_Ex_PK_GTCCGC_R1_001_fastq	EXR-SADAS1Ex7003-BS	total cell-free biofluid RNA	1,974,718	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	2,027,688	Healthy Control	Plasma
070_PK_Vs_ACTTGA	0.838542	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_070_PK_Vs_ACTTGA_R1_001_fastq	EXR-SADAS1Ex7004-BS	extracellular vesicle	2,198,977	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	2,622,380	Healthy Control	Plasma
077_BL_Vs_TGACCA	0.566107	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_077_BL_Vs_TGACCA_combined_2_R1_001_fastq	EXR-SADAS1Ex7701-BS	extracellular vesicle	1,000,344	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	1,767,058	Healthy Control	Plasma
077_Ex_BL_AGTTCC	0.970869	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_077_Ex_BL_AGTTCC_R1_001_fastq	EXR-SADAS1Ex7702-BS	total cell-free biofluid RNA	2,509,513	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	2,584,812	Healthy Control	Plasma
077_Ex_PK_GTGAAA	0.949908	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_077_Ex_PK_GTGAAA_R1_001_fastq	EXR-SADAS1Ex7703-BS	total cell-free biofluid RNA	4,606,619	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	4,849,542	Healthy Control	Plasma
077_PK_Vs_GATCAG	0.378053	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_077_PK_Vs_GATCAG_combined_2_R1_001_fastq	EXR-SADAS1Ex7704-BS	extracellular vesicle	333,378	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	NO	881,828	Healthy Control	Plasma
078_BL_Vs_ACAGTG	0.91251	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_078_BL_Vs_ACAGTG_R1_001_fastq	EXR-SADAS1Ex7801-BS	extracellular vesicle	3,901,117	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	4,275,152	Healthy Control	Plasma
078_Ex_BL_ATGTCA	0.988564	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_078_Ex_BL_ATGTCA_R1_001_fastq	EXR-SADAS1Ex7802-BS	total cell-free biofluid RNA	8,027,788	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	8,120,656	Healthy Control	Plasma
078_Ex_PK_GTGGCC	0.979813	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_078_Ex_PK_GTGGCC_R1_001_fastq	EXR-SADAS1Ex7803-BS	total cell-free biofluid RNA	2,127,188	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	2,171,015	Healthy Control	Plasma
078_PK_Vs_TAGCTT	0.968405	Not Applicable	EXR-SADAS1EXER1-AN	sample_Sample_078_PK_Vs_TAGCTT_R1_001_fastq	EXR-SADAS1Ex7804-BS	extracellular vesicle	5,086,697	Human	Entire body system	MiRVana Paris (Ambion)	small RNA-Seq	YES	5,252,655	Healthy Control	Plasma