ERCC0100430.896134542,550EXR-JFREE1eZDUKB-ANsample_FHS_1020_CVD_BC_12_fastqEntire cardiovascular systemEXR-JFREE11020-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES605,434Cardiovascular Disorder0.866619269,652EXR-JFREE1eZDUKB-ANsample_FHS_1066_No_CVD_BC_11_fastqEntire cardiovascular systemEXR-JFREE11066-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES311,154Healthy Control0.86556333,771EXR-JFREE1eZDUKB-ANsample_FHS_1095_No_CVD_BC_13_fastqEntire cardiovascular systemEXR-JFREE11095-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES385,613Healthy Control0.906389166,607EXR-JFREE1eZDUKB-ANsample_FHS_1120_No_CVD_BC_01_fastqEntire cardiovascular systemEXR-JFREE11120-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES183,814Healthy Control0.8688731,229EXR-JFREE1eZDUKB-ANsample_FHS_1430_CVD_BC_10_fastqEntire cardiovascular systemEXR-JFREE11430-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES841,645Cardiovascular Disorder0.746617183,753EXR-JFREE1eZDUKB-ANsample_FHS_1579_CVD_BC_10_fastqEntire cardiovascular systemEXR-JFREE11579-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES246,114Cardiovascular Disorder0.936471,007,685EXR-JFREE1eZDUKB-ANsample_FHS_1610_CVD_BC_04_fastqEntire cardiovascular systemEXR-JFREE11610-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES1,076,046Cardiovascular Disorder0.768581276,109EXR-JFREE1eZDUKB-ANsample_FHS_172_CVD_BC_14_fastqEntire cardiovascular systemEXR-JFREE10172-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES359,245Cardiovascular Disorder0.9455841,500,424EXR-JFREE1eZDUKB-ANsample_FHS_216_N0_CVD_BC_03_fastqEntire cardiovascular systemEXR-JFREE10216-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES1,586,770Healthy Control0.83462210,235EXR-JFREE1eZDUKB-ANsample_FHS_21_No_CVD_BC_01_fastqEntire cardiovascular systemEXR-JFREE10021-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES251,893Healthy Control0.788773211,627EXR-JFREE1eZDUKB-ANsample_FHS_2303_No_CVD_BC_07_fastqEntire cardiovascular systemEXR-JFREE12303-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES268,299Healthy Control0.790398130,701EXR-JFREE1eZDUKB-ANsample_FHS_2616_No_CVD_BC_05_fastqEntire cardiovascular systemEXR-JFREE12616-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES165,361Healthy Control0.9539221,249,385EXR-JFREE1eZDUKB-ANsample_FHS_2768_CVD_BC_02_fastqEntire cardiovascular systemEXR-JFREE12768-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES1,309,735Cardiovascular Disorder0.9383851,095,028EXR-JFREE1eZDUKB-ANsample_FHS_2918_No_CVD_BC01_fastqEntire cardiovascular systemEXR-JFREE12918-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES1,166,928Healthy Control0.71681588,318EXR-JFREE1eZDUKB-ANsample_FHS_2938_CVD_BC_04_fastqEntire cardiovascular systemEXR-JFREE12938-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqNO123,209Cardiovascular Disorder0.826711177,265EXR-JFREE1eZDUKB-ANsample_FHS_3132_N0_CVD_BC_05_fastqEntire cardiovascular systemEXR-JFREE13132-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES214,422Healthy Control0.75105576,519EXR-JFREE1eZDUKB-ANsample_FHS_3170_No_CVD_BC_07_fastqEntire cardiovascular systemEXR-JFREE13170-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqNO101,882Healthy Control0.946026812,926EXR-JFREE1eZDUKB-ANsample_FHS_320_No_CVD_BC_07_fastqEntire cardiovascular systemEXR-JFREE10320-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES859,306Healthy Control0.838254243,884EXR-JFREE1eZDUKB-ANsample_FHS_3392_CVD_BC_02_fastqEntire cardiovascular systemEXR-JFREE13392-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES290,943Cardiovascular Disorder0.71399559,670EXR-JFREE1eZDUKB-ANsample_FHS_3464_No_CVD_BC_03_fastqEntire cardiovascular systemEXR-JFREE13464-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqNO83,572Healthy Control0.822151148,945EXR-JFREE1eZDUKB-ANsample_FHS_3713_CVD_BC_06_fastqEntire cardiovascular systemEXR-JFREE13713-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES181,165Cardiovascular Disorder0.834504177,837EXR-JFREE1eZDUKB-ANsample_FHS_4043_CVD_BC_04_fastqEntire cardiovascular systemEXR-JFREE14043-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES213,105Cardiovascular Disorder0.80196175,885EXR-JFREE1eZDUKB-ANsample_FHS_4820_No_CVD_BC_13_fastqEntire cardiovascular systemEXR-JFREE14820-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES219,319Healthy Control0.70175346,449EXR-JFREE1eZDUKB-ANsample_FHS_4912_CVD_BC_02_fastqEntire cardiovascular systemEXR-JFREE14912-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqNO66,190Cardiovascular Disorder0.68986490,586EXR-JFREE1eZDUKB-ANsample_FHS_500_No_CVD_BC_09_fastqEntire cardiovascular systemEXR-JFREE10500-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqNO131,310Healthy Control0.822248151,001EXR-JFREE1eZDUKB-ANsample_FHS_5237_CVD_BC_06_fastqEntire cardiovascular systemEXR-JFREE15237-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES183,644Cardiovascular Disorder0.75792391,811EXR-JFREE1eZDUKB-ANsample_FHS_543_CVD_BC_16_fastqEntire cardiovascular systemEXR-JFREE10543-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqNO121,135Cardiovascular Disorder0.842146150,126EXR-JFREE1eZDUKB-ANsample_FHS_590_N0_CVD_BC_15_fastqEntire cardiovascular systemEXR-JFREE10590-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES178,266Healthy Control0.9537631,378,861EXR-JFREE1eZDUKB-ANsample_FHS_6077_No_CVD_BC_09_fastqEntire cardiovascular systemEXR-JFREE16077-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES1,445,706Healthy Control0.825893156,354EXR-JFREE1eZDUKB-ANsample_FHS_6136_CVD_BC_08_fastqEntire cardiovascular systemEXR-JFREE16136-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES189,315Cardiovascular Disorder0.908901727,498EXR-JFREE1eZDUKB-ANsample_FHS_6355_CVD_BC_08_fastqEntire cardiovascular systemEXR-JFREE16355-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES800,415Cardiovascular Disorder0.825828294,681EXR-JFREE1eZDUKB-ANsample_FHS_6684_CVD_BC_16_fastqEntire cardiovascular systemEXR-JFREE16684-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES356,831Cardiovascular Disorder0.766947185,579EXR-JFREE1eZDUKB-ANsample_FHS_6758_CVD_BC_14_fastqEntire cardiovascular systemEXR-JFREE16758-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES241,971Cardiovascular Disorder0.9437561,031,504EXR-JFREE1eZDUKB-ANsample_FHS_676_CVD_BC_06_fastqEntire cardiovascular systemEXR-JFREE10676-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES1,092,977Cardiovascular Disorder0.868186178,532EXR-JFREE1eZDUKB-ANsample_FHS_6926_No_CVD_BC_03_fastqEntire cardiovascular systemEXR-JFREE16926-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES205,638Healthy Control0.804494295,317EXR-JFREE1eZDUKB-ANsample_FHS_7138_CVD_BC_12_fastqEntire cardiovascular systemEXR-JFREE17138-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES367,084Cardiovascular Disorder0.765965466,364EXR-JFREE1eZDUKB-ANsample_FHS_7226_No_CVD_BC_15_fastqEntire cardiovascular systemEXR-JFREE17226-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES608,858Healthy Control0.770573128,725EXR-JFREE1eZDUKB-ANsample_FHS_728_CVD_BC_08_fastqEntire cardiovascular systemEXR-JFREE10728-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES167,051Cardiovascular Disorder0.750356139,705EXR-JFREE1eZDUKB-ANsample_FHS_7326_No_CVD_BC_11_fastqEntire cardiovascular systemEXR-JFREE17326-BStotal cell-free biofluid RNANot ApplicableHumanPlasmamiRcury biofluids (Exiqon)small RNA-SeqYES186,185Healthy Controlunknown21Extracellular RNA from the plasma of 40 individuals from the Framingham Heart Study were isolated using miRCURY RNA isolation kit...27112789/profile/10501/ercc1539574033Jul.30, 2018Falseunknowndiverse-human-extracellular-rnas-are-widely-detectunknownDiverse human extracellular RNAs are widely detected in human plasma.Jul.30, 2018Extracellular RNA from the plasma of 40 individuals from the Framingham Heart Study were isolated using miRCURY RNA isolation kit Biofluids (Exiqon). Small RNA Library preparation was done with Ion Total RNA-Seq Kit v2 (Thermo Fisher Scientific) and the samples were sequenced with the Ion Proton. Next, using a targeted quantitative PCR with reverse transcription approach in 2,763 individuals, we characterized almost 500 of the most abundant extracellular transcripts including microRNAs, piRNAs and small nucleolar RNAs. The presence in plasma of many non-microRNA small-RNAs was confirmed in an independent cohort. We present comprehensive data to demonstrate the broad and consistent detection of diverse classes of circulating non-cellular small-RNAs from a large population.BDS_00032human