ERCCercc_sid10025Not ApplicablePlasmaEntire cardiovascular system230,891smRNA-Seq0.460801501,064NOEXR-DGALA1D3142PFN-BSmiRNeasy (Qiagen)total cell-free biofluid RNAHealthy ControlNot ApplicablePlasmaEntire cardiovascular system142,222smRNA-Seq0.357747397,549NOEXR-DGALA1D3176PFN-BSmiRNeasy (Qiagen)total cell-free biofluid RNAHealthy ControlNot ApplicablePlasmaEntire cardiovascular system155,011smRNA-Seq0.382272405,499NOEXR-DGALA1D3340PMN-BSmiRNeasy (Qiagen)total cell-free biofluid RNAHealthy ControlNot ApplicablePlasmaEntire cardiovascular system29,923smRNA-Seq0.3331489,821NOEXR-DGALA1022163PF-BSmiRNeasy (Qiagen)total cell-free biofluid RNAcolorectal cancerNot ApplicablePlasmaEntire cardiovascular system80,212smRNA-Seq0.418862191,500NOEXR-DGALA1022273PF-BSmiRNeasy (Qiagen)total cell-free biofluid RNAcolorectal cancerNot ApplicablePlasmaEntire cardiovascular system88,709smRNA-Seq0.379583233,701NOEXR-DGALA1022299PM-BSmiRNeasy (Qiagen)total cell-free biofluid RNAcolorectal cancerNot ApplicablePlasmaEntire cardiovascular system52,249smRNA-Seq0.285972182,707NOEXR-DGALA193163PMC-BSmiRNeasy (Qiagen)total cell-free biofluid RNAUlcerative ColitisNot ApplicablePlasmaEntire cardiovascular system50,522smRNA-Seq0.268383188,246NOEXR-DGALA193164PMC-BSmiRNeasy (Qiagen)total cell-free biofluid RNAUlcerative ColitisNot ApplicablePlasmaEntire cardiovascular system199,026smRNA-Seq0.516342385,454YESEXR-DGALA193166PFC-BSmiRNeasy (Qiagen)total cell-free biofluid RNAUlcerative Colitis021Human plasma has long been a rich source for biomarker discovery. It has recently become clear that plasma RNA molecules, such as...23251414/profile/10501/ercc139100422842Apr.05, 2017Falseunknownthe-complex-exogenous-rna-spectra-in-human-plasmaunknownThe Complex Exogenous RNA Spectra in Human Plasma: An Interface with Human Gut Biota?Mar.23, 2017Human plasma has long been a rich source for biomarker discovery. It has recently become clear that plasma RNA molecules, such as microRNA, in addition to proteins are common and can serve as biomarkers. Surveying human plasma for microRNA biomarkers using next generation sequencing technology, we observed that a significant fraction of the circulating RNA appear to originate from exogenous species. With careful analysis of sequence error statistics and other controls, we demonstrated that there is a wide range of RNA from many different organisms, including bacteria and fungi as well as from other species. These RNAs may be associated with protein, lipid or other molecules protecting them from RNase activity in plasma. Some of these RNAs are detected in intracellular complexes and may be able to influence cellular activities under in vitro conditions. These findings raise the possibility that plasma RNAs of exogenous origin may serve as signaling molecules mediating for example the human-microbiome interaction and may affect and/or indicate the state of human health. This is a dataset provided from Extracellular RNA Communication consortium (ERCC). More details are available at <a href="http://exrna-atlas.org/exat/datasets">http://exrna-atlas.org/exat/datasets</a>.BDS_00019human